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Kevin McKernan

๐Ÿ‘ค Speaker
1467 total appearances

Appearances Over Time

Podcast Appearances

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

I think there is โ€“ probably 100,000 years ago was when the diaspora was most extreme. Although you can find obviously hominids back a million years. They go as far back as Australopithecus. We haven't gotten sequence from material that's that old. I think some of the records and sequencing are probably โ€“ 50 or 100,000 years. I haven't kept directly up to speed with it.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

Svante probably has the record on the oldest thing ever sequenced. But that's โ€“ yeah, I haven't kept up with the human population genomics story there because in some ways it's very boring. Yeah. It's, as you said, there's not a lot to it. We all came from a fairly recent ancestor.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

Svante probably has the record on the oldest thing ever sequenced. But that's โ€“ yeah, I haven't kept up with the human population genomics story there because in some ways it's very boring. Yeah. It's, as you said, there's not a lot to it. We all came from a fairly recent ancestor.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

Svante probably has the record on the oldest thing ever sequenced. But that's โ€“ yeah, I haven't kept up with the human population genomics story there because in some ways it's very boring. Yeah. It's, as you said, there's not a lot to it. We all came from a fairly recent ancestor.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

And it's, you know, you can't find some interesting things about the genetics that change with lactose tolerance based on when we think we went through, you know, when we began to get involved in agriculture and a more, you know, farm-based lifestyle. So there are some, you know, genetics that

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

And it's, you know, you can't find some interesting things about the genetics that change with lactose tolerance based on when we think we went through, you know, when we began to get involved in agriculture and a more, you know, farm-based lifestyle. So there are some, you know, genetics that

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

And it's, you know, you can't find some interesting things about the genetics that change with lactose tolerance based on when we think we went through, you know, when we began to get involved in agriculture and a more, you know, farm-based lifestyle. So there are some, you know, genetics that

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

No, I mean, the thing that's really unique about humans is that we're very adaptable and we can move. And as a result, I think, you'll find that our genomes aren't nearly as complex as plants. Plants are sessile, so they're stuck. When the environment changes, they can't run away from it. They have to carry a lot more genomic tricks in their bag to compensate for it.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

No, I mean, the thing that's really unique about humans is that we're very adaptable and we can move. And as a result, I think, you'll find that our genomes aren't nearly as complex as plants. Plants are sessile, so they're stuck. When the environment changes, they can't run away from it. They have to carry a lot more genomic tricks in their bag to compensate for it.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

No, I mean, the thing that's really unique about humans is that we're very adaptable and we can move. And as a result, I think, you'll find that our genomes aren't nearly as complex as plants. Plants are sessile, so they're stuck. When the environment changes, they can't run away from it. They have to carry a lot more genomic tricks in their bag to compensate for it.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

So, in fact, there's a very good and interesting piece of work I'd forward you to from David Sinclair, who works on a lot of this longevity stuff. Yeah. He was digging around in the xenohormesis field, which I think is fascinating. It's kind of an intersection of cannabis and human genetics.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

So, in fact, there's a very good and interesting piece of work I'd forward you to from David Sinclair, who works on a lot of this longevity stuff. Yeah. He was digging around in the xenohormesis field, which I think is fascinating. It's kind of an intersection of cannabis and human genetics.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

So, in fact, there's a very good and interesting piece of work I'd forward you to from David Sinclair, who works on a lot of this longevity stuff. Yeah. He was digging around in the xenohormesis field, which I think is fascinating. It's kind of an intersection of cannabis and human genetics.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

Plants, as we became agriculturally centered as a society, and this has probably happened long before that occurred, but plants have this capacity of making secondary metabolites that signal to the organisms that eat them and spread their seed around They give information about the environment.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

Plants, as we became agriculturally centered as a society, and this has probably happened long before that occurred, but plants have this capacity of making secondary metabolites that signal to the organisms that eat them and spread their seed around They give information about the environment.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

Plants, as we became agriculturally centered as a society, and this has probably happened long before that occurred, but plants have this capacity of making secondary metabolites that signal to the organisms that eat them and spread their seed around They give information about the environment.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

So a lot of the secondary metabolites that you'll find in plants when they're stressed will signal to the organism that consumes them to prepare with caloric restriction. So you'll see many of the compounds that hit the rapamycin pathway and the mTOR pathway are polyphenols and flavonoids and things plants create when they're stressed out. Whoa.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

So a lot of the secondary metabolites that you'll find in plants when they're stressed will signal to the organism that consumes them to prepare with caloric restriction. So you'll see many of the compounds that hit the rapamycin pathway and the mTOR pathway are polyphenols and flavonoids and things plants create when they're stressed out. Whoa.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

So a lot of the secondary metabolites that you'll find in plants when they're stressed will signal to the organism that consumes them to prepare with caloric restriction. So you'll see many of the compounds that hit the rapamycin pathway and the mTOR pathway are polyphenols and flavonoids and things plants create when they're stressed out. Whoa.

Danny Jones Podcast
#270 - DNA Expert Warns of Mysterious New 'Turbo Cancer' Outbreak | Kevin McKernan

So this is one of these, this is something we pay attention to in the cannabis field, because if you want to get very diverse chemotypes of plants, you can't grow them in perfectly happy environments. Like you actually want to stress them to some extent so that you get anthocyanins to come up. When you stress them, you tend to get different terpene profiles.