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Luke O'Neill

👤 Speaker
1510 total appearances

Appearances Over Time

Podcast Appearances

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

So, freely available.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

But that will be used immediately, watch, because it's freely available.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

And what's the other development?

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

This is more exciting because this is more experimental.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

GSK, the drug company, give them credit.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

A drug called Mores.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

Now, there's a mouthful for you.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

They developed this drug called Mores and they got a 62% response rate, which meant 62% of people responded really well.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

Their tumours shrank and were eliminated.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

Yeah.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

With ovarian cancer.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

Eliminate.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

Yeah, and some of these people with this drug, and it's a very powerful drug.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

In ovarian cancer, the cancer cells overexpress a thing called B7H4 on their surface, like a flag goes up on the cancer cell.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

Yeah.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

This was a drug, an antibody that could lock onto that.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

And it carried a poison with it.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

They're called antibody drug conjugates.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

So you attach a nasty chemical to an antibody that targets this thing, B7H4, and the chemical kills the cell.

The Pat Kenny Show
Luke O’Neill with some promising advances in treating pancreatic & ovarian cancer

There's been a few ideas around this already in the past.