Mary Lynn McPherson
speaker
498 appearances
2 recordings
1 series
first heard Oct 2018
last heard Dec 2021
Mary Lynn McPherson’s voice in public audio — every appearance, attributed to the second.
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Appearances
Maybe you need to be a little more aggressive.
Maybe you're switching because now the patient uh can't swallow tablets or capsules anymore, but they were very, very comfortable.
Maybe you're switching for s whatever the reason may be.
So then you have to take into consideration, what am I gonna do with this number?
generally you don't roll with that number.
For one thing, it's probably a goofy number that you can't actually do with tablets and capsules that are commercially available if it's the oral route of administration.
If a patient was switching because of a side effect and their pain was well controlled,
Another important consideration is are you switching from one opioid to a different opioid?
So if you're going to a different molecule
They will be more sensitive to the new molecule.
So you probably should reduce it.
Now, as I said earlier, what's confounding the situation is we have steady state data looking at going from IV dilotid to oromorphine, for example, which kind of took into consideration that lack of complete cross tolerance.
So I probably would not cut back as much, but this is where you have to put on your thinking cap.
Sometimes I'll reduce that by 50%.
Sometimes I'll reduce it by maybe fifteen percent.
Rule of thumb is about a third.
very ch Go ahead.
five half lives.
Five
Mm-hmm.
Showing 181–200 of 498 · page 10 of 25
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