Mary Lynn McPherson
speaker
498 appearances
2 recordings
1 series
first heard Oct 2018
last heard Dec 2021
Mary Lynn McPherson’s voice in public audio — every appearance, attributed to the second.
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Appearances
So for example,
Morphine is the most water soluble of all the opioids.
So only about twenty percent of that dose gets transmucosally absorbed.
But that's okay.
It kinda hangs in the buccal cavity there and trickles down the throat very slowly, just like they had swallowed it, which is fine.
That's perfectly fine.
You look at a drug like fentanyl, which is one of the most lipid soluble drugs, probably closer to fifty percent of that drug gets absorbed transmucosally, which is why
We have six transmucosal fentanyl products on the market.
Because you have better absorption because of the lipid solubility.
Well, we do know, uh, clinically and anecdotally, that people who are very wasted and cacectic, if you use transdermal fentanyl, they really don't seem to get the bang for the buck that you would expect.
There's some data from uh uh Norwegian country, for example.
Um but uh why is this?
I and we're not a hundred percent sure.
It could be that, you know, being a very fat soluble drug, if somebody's skin and bones literally
Can you find a little fat pad to apply the patch?
That may be part of it.
It may be partly the drug what does get absorbed kind of looks around and sees it's got nowhere to hang and says, Well, I guess I'll get out of dodge now.
But we also know, for example, that cancer patients, the fentanyl is pretty highly bound to albumin.
And with cancer, the fentanyl albumin combination goes into the extravascular space and hangs.
So it's not in the central circulation.
Showing 301–320 of 498 · page 16 of 25
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