Mary Lynn McPherson
speaker
498 appearances
2 recordings
1 series
first heard Oct 2018
last heard Dec 2021
Mary Lynn McPherson’s voice in public audio — every appearance, attributed to the second.
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Appearances
So you've got to be very careful.
If someone is on a traditional opioid, you just can't throw buprenorphine on top of it because you could throw the patient in the withdrawal because the mu receptor is far more attracted to buprenorphine than the morphine, um, oxycodone crew.
But you could use any opioid and add it to buprenorphine.
So I do think we have some work there.
I think uh w it would be nice.
I heard that California just came out with um a buprenorphine generic that we could could start to use for pain that is very cost effective.
So I think
We're very close to that point and I would like to see us explore that.
It means it doesn't bind fully to the receptor.
And there's probably people say, is there or isn't there a ceiling effect in analgesia, where if you're looking at an XY axis there, you know, the more you give of the drug, the more pain relief you get.
You go up, up, up.
But at a certain point that line's gonna level off.
That even if you continue to give more and more drug, you don't get any additional pain relief.
But now people are arguing that's a pretty high limit where you start to see that.
The good news is with buprenorphine is we probably see a bit less respiratory depression because of this pharmacologic property.
So um my good friend Dr.
Mel Davis is a huge buprenorphine fan.
He wrote a wonderful article about twelve things everybody should know about buprenorphine.
It's it's worth a a quick read.
I think it's a very interesting molecule and I think we are on the cusp of learning to use it more effectively in clinical practice.
Showing 381–400 of 498 · page 20 of 25
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