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Mike Israetel

๐Ÿ‘ค Speaker
2772 total appearances

Appearances Over Time

Podcast Appearances

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

We need to rage out on someone. If you're on a lot of testosterone, you're more likely to be like, I wonder if he'd say that to my face. I wonder if he would be real quiet around me because he would know that I'm not someone to be messed with. weird, weird thoughts like that. Women almost never have thoughts like that. Men have regular thoughts like that in the right context.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

People on steroids have more thoughts like that in almost every context than on average they would like to have. Another one is you become linguistically less expressive and your fluidity of communication falls. So a lot of times when someone is using high levels of anabolic steroids in a relationship and that person happens to be male, the degree of communicative throughput falls substantially.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

People on steroids have more thoughts like that in almost every context than on average they would like to have. Another one is you become linguistically less expressive and your fluidity of communication falls. So a lot of times when someone is using high levels of anabolic steroids in a relationship and that person happens to be male, the degree of communicative throughput falls substantially.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

Just generally not good for most relationships. Another one is sex drive. It's difficult for women to appreciate what the male sex drive is like on a quantitative and qualitative level. Both of those tend to magnify, especially if you're not bringing your estrogen down. You bring estrogen low enough, you don't even remember what the hell sex is for or why people are even in it, that sort of thing.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

Just generally not good for most relationships. Another one is sex drive. It's difficult for women to appreciate what the male sex drive is like on a quantitative and qualitative level. Both of those tend to magnify, especially if you're not bringing your estrogen down. You bring estrogen low enough, you don't even remember what the hell sex is for or why people are even in it, that sort of thing.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

But if you have a lot of androgens, a lot of estrogen, the hunger, the thirst becomes very annoying.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

But if you have a lot of androgens, a lot of estrogen, the hunger, the thirst becomes very annoying.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

That's left alone? It depends. It depends on a few things. One is different people respond differently, both physique and psychology, to high levels of estrogen. High levels of estrogen for some people are like swimming in a pool of magical clouds, and they love it. And their physique looks great. They get nice and watery. Their joints feel amazing. Their recovery is awesome.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

That's left alone? It depends. It depends on a few things. One is different people respond differently, both physique and psychology, to high levels of estrogen. High levels of estrogen for some people are like swimming in a pool of magical clouds, and they love it. And their physique looks great. They get nice and watery. Their joints feel amazing. Their recovery is awesome.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

Their sleep is awesome. Sex drive is awesome. Everything's great. For some other people, they get a lot of estrogen, and it actually prevents them from getting good sleep at higher levels. They're water buffalo bloated, and they can't even see their abs anymore, even though they're 8% body fat. And they get mood swings, all this crazy stuff. And so it really is very individually dependent.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

Their sleep is awesome. Sex drive is awesome. Everything's great. For some other people, they get a lot of estrogen, and it actually prevents them from getting good sleep at higher levels. They're water buffalo bloated, and they can't even see their abs anymore, even though they're 8% body fat. And they get mood swings, all this crazy stuff. And so it really is very individually dependent.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

The other thing is what we're learning in evidence-based approach to anabolic steroid utilization and performance-enhancing drug utilization, it's called the safer use model.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

The other thing is what we're learning in evidence-based approach to anabolic steroid utilization and performance-enhancing drug utilization, it's called the safer use model.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

Probably the biggest promulgator of it is a gentleman named Joe Jeffrey in the United Kingdom, super, super expert, exceptional bodybuilding coach, great bodybuilders in their own right, who just reads literature all day long. And folks like him tend to espouse that probably the best way to manage estrogen is

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

Probably the biggest promulgator of it is a gentleman named Joe Jeffrey in the United Kingdom, super, super expert, exceptional bodybuilding coach, great bodybuilders in their own right, who just reads literature all day long. And folks like him tend to espouse that probably the best way to manage estrogen is

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

is to use some combination of exogenous drugs that are androgens themselves to get the estrogen level you have the best notable metrics at, how you feel, how you look, how your blood work is, health, et cetera. So here's an example. You take 1,000 milligrams of testosterone. I'm still wrapping my head around this. It actually goes into your thigh in a needle.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

is to use some combination of exogenous drugs that are androgens themselves to get the estrogen level you have the best notable metrics at, how you feel, how you look, how your blood work is, health, et cetera. So here's an example. You take 1,000 milligrams of testosterone. I'm still wrapping my head around this. It actually goes into your thigh in a needle.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

You don't have to wrap your head around. So it's intense. It's a lot. You take 1,000 milligrams of testosterone, and that comes with a concomitant aromatization, so you have a lot of estrogen. Some people, they feel totally great. For some people, it's too much. For those who it's too much estrogen, they might be able to take 500 milligrams of testosterone and then 500 milligrams of primobolin.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

You don't have to wrap your head around. So it's intense. It's a lot. You take 1,000 milligrams of testosterone, and that comes with a concomitant aromatization, so you have a lot of estrogen. Some people, they feel totally great. For some people, it's too much. For those who it's too much estrogen, they might be able to take 500 milligrams of testosterone and then 500 milligrams of primobolin.

The Peter Attia Drive
#335 โ€’ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.

Primobolin is a synthetic anabolic androgenic steroid developed in, I think, the 60s and 70s. And it's designed not really to convert into estrogen hardly at all. Other steroids like it are master on. They not only don't convert into estrogen, but they actually antagonize estrogen conversion for the testosterone you're shooting in to some extent.