Norman Swann

speaker

14,464 appearances 150 recordings 1 series first heard Jul 2005 last heard Feb 2013

Norman Swann’s voice in public audio — every appearance, attributed to the second.

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Health Report · Monday 04 January 2010 · 3 Jan 2010 podcast

A British study has confirmed some of what Changa Zgula was saying, which is that as we age, what pathologists might see in the brain isn't necessarily reflected in how well people's thinking abilities and memory hold up. voice-verified

It has enormous implications for finding new treatments and indeed prevention. voice-verified

Stephen Wharton is a neuropathologist at the University of Sheffield voice-verified

And when you say population, sorry to interrupt, but when you say population, these are people from the community at large, therefore reasonably representative of the British population? voice-verified

And they've donated their brains? voice-verified

And you made really quite a surprising finding. voice-verified

So voice-verified

which basically look as if they're messing up the brain, there was already a doubt that they may be highly specific to Alzheimer's disease. voice-verified

So tell us what you found. voice-verified

So in other words, you're seeing people without dementia who, if you were to look at it down the microscope, say, well, this person is clearly demented, but in fact they were as bright as a button. voice-verified

So given there's less of a difference, you have to question a couple of things. voice-verified

First of all, is it cause and effect? voice-verified

And the second one is, is dementia a different disease if you survive to 90? voice-verified

I voice-verified

So some people might have a gene which gives them resistance to those. voice-verified

So despite the fact that they've got them, it doesn't bother them. voice-verified

So have you correlated this, given it's a population group and you're looking at all sorts of other things in these people? voice-verified

It's been said, for example, that Alzheimer's disease is not quite so pure a disease as people have suggested. voice-verified

Then there's a definite overlap with what's called vascular dementia, where if you've got diseased arteries like coronary heart disease, then you're more likely to get an Alzheimer's disease type picture or even perhaps trigger these plaques and tangles. voice-verified

and that some people are suggesting a healthy lifestyle actually is good for your brain. voice-verified

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