Oleg Nodelman
speaker
220 appearances
2 recordings
2 series
first heard Jun 2026
last heard 12 Jun
Oleg Nodelman’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 2 in all, peaking in Jun 2026 with 2.
Appearances
We're lucky to have long-term partners, many of whom are biotech entrepreneurs themselves and have been with us since day one.
And we recently reopened for the first time in four years.
Today, I'm going to tell you about a company that's on the front lines of the war on cancer.
Military terminology has been used when describing treatments for the disease since the early 70s, when President Nixon signed the National Cancer Act.
The warfare analogy is actually perfect.
The warfare is actually perfect for cancer because both domains are trying to accomplish the exact same thing.
Find the enemy, figure out the best weapon to kill them, and have minimal unwanted casualties along the way.
First, a quick history of how this war has evolved.
Early surgical cancer treatment and radiation was akin to a medieval siege.
Level the entire castle, burn the surrounding village, and hope the enemy was left somewhere in the rubble.
Chemo actually evolved from an accidental observation during World War I that mustard gas killed rapidly dividing tissue.
Tumor cells divide fast, so doctors would flood a patient's body with chemo and hoped it killed the enemy faster than it killed allies.
Unfortunately, hair, skin, gut, and marrow cells also divide quickly, and the poison doesn't discriminate.
First-generation targeted therapies were next, like a GPS-guided munition.
Instead of carpet bombing every dividing cell, you identify the enemy's command and control center and destroy it.
The problem, like with any weapon, is that the enemy adapts and hides.
And in cancer, these are called resistant mutations.
Immunotherapy was first introduced to patients a decade ago.
With IO, you don't send in your own troops.
You recruit local allies, also known as T-cells, and let them do the fighting for you.
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