Paul Saladino, MD

Yeah, but what's going on is we are stuffing our cell membranes and we are stuffing our mitochondrial membranes with polyunsaturated fatty acids. Our bodies change based on what we're eating. This is the thing that not all calories are created equally. The last time we talked, we talked about my frustration with the notion that you can just eat less calories

Yeah, but what's going on is we are stuffing our cell membranes and we are stuffing our mitochondrial membranes with polyunsaturated fatty acids. Our bodies change based on what we're eating. This is the thing that not all calories are created equally. The last time we talked, we talked about my frustration with the notion that you can just eat less calories

Yeah, but what's going on is we are stuffing our cell membranes and we are stuffing our mitochondrial membranes with polyunsaturated fatty acids. Our bodies change based on what we're eating. This is the thing that not all calories are created equally. The last time we talked, we talked about my frustration with the notion that you can just eat less calories

and even eat bad food, that you can somehow out diet or out exercise a bad diet. And it's not true because if you are eating French fries, yes, you could lose weight eating French fries, but you are immediately stuffing all of your cell membranes, all of your mitochondrial membranes, all of the cells in your fatty acid depots with more polyunsaturated fatty acids. We are in flux.

and even eat bad food, that you can somehow out diet or out exercise a bad diet. And it's not true because if you are eating French fries, yes, you could lose weight eating French fries, but you are immediately stuffing all of your cell membranes, all of your mitochondrial membranes, all of the cells in your fatty acid depots with more polyunsaturated fatty acids. We are in flux.

and even eat bad food, that you can somehow out diet or out exercise a bad diet. And it's not true because if you are eating French fries, yes, you could lose weight eating French fries, but you are immediately stuffing all of your cell membranes, all of your mitochondrial membranes, all of the cells in your fatty acid depots with more polyunsaturated fatty acids. We are in flux.

And so evolutionarily inappropriate diets of polyunsaturated fatty acids that are already oxidized and susceptible to further oxidation in the human body are causing major issues for people. And I think that there's mechanistic data that points to the actual problem here. There is evidence that as the membrane of your mitochondria becomes more highly polyunsaturated, you actually get proton leak.

And so evolutionarily inappropriate diets of polyunsaturated fatty acids that are already oxidized and susceptible to further oxidation in the human body are causing major issues for people. And I think that there's mechanistic data that points to the actual problem here. There is evidence that as the membrane of your mitochondria becomes more highly polyunsaturated, you actually get proton leak.

And so evolutionarily inappropriate diets of polyunsaturated fatty acids that are already oxidized and susceptible to further oxidation in the human body are causing major issues for people. And I think that there's mechanistic data that points to the actual problem here. There is evidence that as the membrane of your mitochondria becomes more highly polyunsaturated, you actually get proton leak.

So the mitochondria is quite a complex little organelle, right? Probably evidence of endosymbiosis, this primordial... connection that we had with some sort of a bacteria hundreds of millions of years ago, where a nucleated organism actually engulfed a bacteria and that bacteria started working for us. And now we have trillions of these mitochondria in our bodies.

So the mitochondria is quite a complex little organelle, right? Probably evidence of endosymbiosis, this primordial... connection that we had with some sort of a bacteria hundreds of millions of years ago, where a nucleated organism actually engulfed a bacteria and that bacteria started working for us. And now we have trillions of these mitochondria in our bodies.

So the mitochondria is quite a complex little organelle, right? Probably evidence of endosymbiosis, this primordial... connection that we had with some sort of a bacteria hundreds of millions of years ago, where a nucleated organism actually engulfed a bacteria and that bacteria started working for us. And now we have trillions of these mitochondria in our bodies.

And this is the way that our bodies convert food energy into kinetic energy. It's through the mitochondria. This is where beta oxidation and glycolysis happen. or the downstream biochemistry after glycolysis happened in the mitochondria. So this is where the Krebs cycle happens.

And this is the way that our bodies convert food energy into kinetic energy. It's through the mitochondria. This is where beta oxidation and glycolysis happen. or the downstream biochemistry after glycolysis happened in the mitochondria. So this is where the Krebs cycle happens.

And this is the way that our bodies convert food energy into kinetic energy. It's through the mitochondria. This is where beta oxidation and glycolysis happen. or the downstream biochemistry after glycolysis happened in the mitochondria. So this is where the Krebs cycle happens.

And so in order to convert food energy, which is potential energy, to kinetic energy, actual usable ATP, which we use to repair DNA, to make hormones, to make cellular processes, to rebuild our bodies, to run our brains, everything in our body happens with kinetic energy, ATP, that comes from food. But in between are our mitochondria.

And so in order to convert food energy, which is potential energy, to kinetic energy, actual usable ATP, which we use to repair DNA, to make hormones, to make cellular processes, to rebuild our bodies, to run our brains, everything in our body happens with kinetic energy, ATP, that comes from food. But in between are our mitochondria.

And so in order to convert food energy, which is potential energy, to kinetic energy, actual usable ATP, which we use to repair DNA, to make hormones, to make cellular processes, to rebuild our bodies, to run our brains, everything in our body happens with kinetic energy, ATP, that comes from food. But in between are our mitochondria.

So potential energy in food, kinetic energy used to make a vital, fertile, happy, healthy human being, in between is our mitochondria. If you break the mitochondria, and you've spoken about this at length, if you break the mitochondria, you get stuck with potential energy. And what does that look like? That looks like fat humans. And so it's not just about calories. Fat, insulin-resistant humans.

So potential energy in food, kinetic energy used to make a vital, fertile, happy, healthy human being, in between is our mitochondria. If you break the mitochondria, and you've spoken about this at length, if you break the mitochondria, you get stuck with potential energy. And what does that look like? That looks like fat humans. And so it's not just about calories. Fat, insulin-resistant humans.