Paul Saladino

We want humans to live long and live well, like the Hadza. We want squaring of the morbidity curve. We want humans to be vital into old age. I'm not excited about giving someone an increased rate of diabetes or dementia, myopathy, lower libido, decreased sex hormones by lowering their cholesterol with a statin. That doesn't solve the problem to me.

We want humans to live long and live well, like the Hadza. We want squaring of the morbidity curve. We want humans to be vital into old age. I'm not excited about giving someone an increased rate of diabetes or dementia, myopathy, lower libido, decreased sex hormones by lowering their cholesterol with a statin. That doesn't solve the problem to me.

We want humans to live long and live well, like the Hadza. We want squaring of the morbidity curve. We want humans to be vital into old age. I'm not excited about giving someone an increased rate of diabetes or dementia, myopathy, lower libido, decreased sex hormones by lowering their cholesterol with a statin. That doesn't solve the problem to me.

We have to understand what is causing the insulin resistance. And so I'll just talk about that because it kind of wraps back to seed oils. And I'm sorry this has been so technical and such a long story, but it's a big Gordian knot, all of this. So I mentioned this earlier, metabolic dysfunction, insulin resistance, this primarily happens at the level of the mitochondria.

We have to understand what is causing the insulin resistance. And so I'll just talk about that because it kind of wraps back to seed oils. And I'm sorry this has been so technical and such a long story, but it's a big Gordian knot, all of this. So I mentioned this earlier, metabolic dysfunction, insulin resistance, this primarily happens at the level of the mitochondria.

We have to understand what is causing the insulin resistance. And so I'll just talk about that because it kind of wraps back to seed oils. And I'm sorry this has been so technical and such a long story, but it's a big Gordian knot, all of this. So I mentioned this earlier, metabolic dysfunction, insulin resistance, this primarily happens at the level of the mitochondria.

If you cannot take substrate from food, which is glucose or fatty acids, and process them into NIDH and FADH2, and move those electrons through the electron transport chain to make ATP, you are going to become insulin resistant. So how does that get broken? It gets broken in two major ways. The first of these is seed oils, and the second of those is sugar. And I'll talk about sugar in a minute.

If you cannot take substrate from food, which is glucose or fatty acids, and process them into NIDH and FADH2, and move those electrons through the electron transport chain to make ATP, you are going to become insulin resistant. So how does that get broken? It gets broken in two major ways. The first of these is seed oils, and the second of those is sugar. And I'll talk about sugar in a minute.

If you cannot take substrate from food, which is glucose or fatty acids, and process them into NIDH and FADH2, and move those electrons through the electron transport chain to make ATP, you are going to become insulin resistant. So how does that get broken? It gets broken in two major ways. The first of these is seed oils, and the second of those is sugar. And I'll talk about sugar in a minute.

Next. Seed oils, I think, are a problem at the level of the mitochondria because that linoleic acid is the most common, most abundant polyunsaturated fat that we consume today as westernized Americans. And that linoleic acid accumulates in the membranes of the mitochondria.

Next. Seed oils, I think, are a problem at the level of the mitochondria because that linoleic acid is the most common, most abundant polyunsaturated fat that we consume today as westernized Americans. And that linoleic acid accumulates in the membranes of the mitochondria.

Next. Seed oils, I think, are a problem at the level of the mitochondria because that linoleic acid is the most common, most abundant polyunsaturated fat that we consume today as westernized Americans. And that linoleic acid accumulates in the membranes of the mitochondria.

And there's evidence from animal models and cell culture that when you have excess linoleic acid from seed oils in the mitochondrial membrane, you get proton leak. And the whole point of the electron transfer chain is to create a gradient that the protons can flow down to make ATP. If you are leaking protons across down the gradient, you are making less ATP.

And there's evidence from animal models and cell culture that when you have excess linoleic acid from seed oils in the mitochondrial membrane, you get proton leak. And the whole point of the electron transfer chain is to create a gradient that the protons can flow down to make ATP. If you are leaking protons across down the gradient, you are making less ATP.

And there's evidence from animal models and cell culture that when you have excess linoleic acid from seed oils in the mitochondrial membrane, you get proton leak. And the whole point of the electron transfer chain is to create a gradient that the protons can flow down to make ATP. If you are leaking protons across down the gradient, you are making less ATP.

At the cellular membrane, we also know that excess linoleic acid, excess polyunsaturated fats creates leak and problems or overactivation of the sodium potassium ATPase. That's all very technical, but suffice it to say that my concern is that when you stuff yourself full of seed oils, you are creating an ATP leak in your body. You are not producing energy as well.

At the cellular membrane, we also know that excess linoleic acid, excess polyunsaturated fats creates leak and problems or overactivation of the sodium potassium ATPase. That's all very technical, but suffice it to say that my concern is that when you stuff yourself full of seed oils, you are creating an ATP leak in your body. You are not producing energy as well.

At the cellular membrane, we also know that excess linoleic acid, excess polyunsaturated fats creates leak and problems or overactivation of the sodium potassium ATPase. That's all very technical, but suffice it to say that my concern is that when you stuff yourself full of seed oils, you are creating an ATP leak in your body. You are not producing energy as well.

And that leads to metabolic dysfunction. And that is actually the root molecular cause. What's the solution? Stop eating so much linoleic acid. Return to a historically accurate, a historically consistent amount of fat. We're doing these... historically inappropriate things, right? We're doing historically inappropriate lights, we're doing historically inappropriate types of fat.

And that leads to metabolic dysfunction. And that is actually the root molecular cause. What's the solution? Stop eating so much linoleic acid. Return to a historically accurate, a historically consistent amount of fat. We're doing these... historically inappropriate things, right? We're doing historically inappropriate lights, we're doing historically inappropriate types of fat.