#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
So once you go to 12.5 and 15, which are the two highest doses, you're still getting a benefit, but it's like most drugs, you're getting most of the benefit at the lowest dose.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
So five to 7.5 milligrams of triseptide is probably where you're getting the majority of the benefit.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
I'd much rather a patient be sort of slow and steady on it as opposed to try to go for maximum and rapid weight loss.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
I mean, I think all of this stuff has to be paid attention to.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
And I think the question, again, comes back to how much of that is occurring due to training, how much of that is happening due to the loss of amino acid intake and the loss of training.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
looked into this a lot because it's funny, we did a podcast on this somewhat recently where I went through this particular question, which is, will GLP-1 receptor agonists ultimately prove to be geroprotective?
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
I came up with a very obscure way to define that, which is,
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
Because obviously at the macro level, they're going to be geroprotective because if you apply them to people with type 2 diabetes and significant obesity and you correct the metabolic dysfunction, you're going to live longer.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
But the real question is, if you take a person who is...
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
of normal weight who does not have type 2 diabetes, but maybe has a higher risk for Alzheimer's disease, and you microdose them.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
So you're giving them 2.5 milligrams per day, which by the way, we are doing in some patients for obscure metabolic condition without obesity.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
So we have patients who have diabetes, but are already at very low body weight.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
We have two patients actually in our practice in this regard.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
After lots of detailed back and forth machination with Ralph DeFranza, who's a previous guest on the podcast, we sort of realized that at least one component of the drug regimen for these patients was going to be a GLP-1 agonist.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
Now, it seemed very counterintuitive to give trizepatide to people who have a BMI of 23, but we've been able to do it without them losing weight.
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
So again, very careful strategies around nutrition and the effect on their diabetes is profound.