Philip Gehrman, PhD

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228 appearances 1 recordings 1 series first heard Jul 2026 last heard 8 Jul

Philip Gehrman, PhD’s voice in public audio — every appearance, attributed to the second.

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Speaking of Psychology · Rethinking sleep and mental health, with Philip Gehrman, PhD · 8 Jul 2026 podcast

Uh it is, to my knowledge, the only potentially beneficial effect of sleep deprivation.

Um and sometimes we call it therapeutic sleep deprivation, or people have also used the term wake therapy, which sounds not as as bad as sleep as therapeutic sleep deprivation.

But uh there's decades of research showing

that uh oh one night of total sleep deprivation is associated with improvement of depression in about 50% of individuals.

And so prior to some of the newer research on things like ketamine, it it was long been known as the fastest antidepressant response that we have.

Now the disadvantage of it is that typically when people go back to sleep, their depression returns.

So it has very rapid effects, but not very sustained effects.

Yeah, and that's what research has been, including our own, has been trying to figure out is how can we figure out who is going to respond to sleep deprivation and who isn't?

And so we did some research looking for uh neuroimaging markers and we found some kind of patterns of connectivity in the brain that had some predictive ability to see kind of who was going to do well.

Um, there's some theories out there that depending on people,

people's kind of biological rhythms that that might predict whether they respond.

Subtypes of depression may respond better than others.

And so it's still a bit of a mystery, but people are have for years tried to figure out what's different about these people who respond.

Absolutely.

And I hope no one listening to this takes away that they should go home and sleep deprived themselves or s have their teller patients to do that, because when it is done, it's done in controlled, highly monitored settings.

Circadian rhythms are the daily, approximately 24-hour rhythms in our body.

And what we've learned is that just about everything in our biology follows a daily rhythm.

So our body temperature has a very strong circadian or daily rhythm.

The levels of the different hormones in our body cycle in a 24-hour rhythm.

Even our DNA, about two-thirds of our gene

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