Professor Luke O'Neill

a psoriatic lesion and they'll be anti-inflammatory but you can't use them long term because they have side effects the steroids are used a bit but now block and aisle 17 amazing results it's incredible and there's several drugs out there you know the block aisle 17 that was the first big breakthrough and it's like night and day literally after a few weeks on aisle 17 drugs to block that

you see the skin begins to clear magically and the skin is almost normal again.

And that's the big breakthrough.

The second one is IL-23, as I mentioned.

Now, guess what IL-23 does?

It induces IL-17.

So it's upstream, if you like.

And the immune system is often like that.

Like dominoes, I suppose.

So the IL-23 domino knocks over the IL-17 domino and then you get psoriasis.

So lo and behold, companies begin to develop ways to block IL-23.

And these work just as well.

So sometimes someone might respond better to an IL-23 targeted therapy than IL-17.

There's options now.

Dermatologists are delighted.

because they've got a few weapons to use now against this disease.

The main IL-23 drug is called Skyrizzy, made by AbbVie.

Again, there's several of them, and it's just examples.

Skyrizzy and Cosentix are trade names for these.

And these are making a massive difference.