Rhonda Patrick, Ph.D.

I mean, so the more

intense the the exercise stimulus you're in you're actually generating inflammatory compounds il-6 being like the big one and and that il-6 is is actually a signals to you know have this anti-inflammatory response so it's funny if you look at the curves you'll see like a timing effect where it's like il-6 peaks and then like it shifts like i don't remember how much later it is maybe an hour or so you start to see il-10 which is an anti-inflammatory cytokine

I'm not talking about in this study.

I'm talking about other studies that have looked at inflammatory biomarkers.

But you'll see this strong anti-inflammatory response.

And this is part of that, you know, something I've talked about before in the podcast for several years is this hormetic response where you're engaging in this type of response.

stressful activity which in this case we're talking about physical activity and the more vigorous it is the more stressful it is and that is a stress on the body and that does cause inflammation it does cause oxidative stress it's causing it's a stress on the body but your body is able to adapt to that and the adaptations is really what we're going for right and so the stronger you're getting this inflammatory response the

You're getting that anti-inflammatory response that then lasts, right?

It's not just like countering the little bit of inflammation that you generated during your workout.

It lasts throughout the day.

And so as you experience other stressful things in life, whether it's you ate a bag of chips or whatever, I mean, obviously, you're going to have the calorie intake, but

the inflammation generated, you're going to deal with it just a little bit better than if you hadn't have been physically active, right?

And so the inflammation and the anti-inflammatory adaptation that's responding to that inflammation is also important because inflammation is a driver of many chronic diseases, including cardiovascular disease, including cancer, type 2 diabetes.

It plays a role in everything, brain aging.

And we didn't get into that, but I do feel like this is a good time

to just mention it because we're talking about mechanisms.

And I've mentioned the lactate signaling molecule.

We know that lactate generated from exercise, particularly as you get into that vigorous type of exercise, that it does get into the brain.

There's actually human studies showing that it gets into the brain.

And we know it's a signaling molecule for brain-derived neurotrophic factor, very important growth factor for brain health, to grow new neurons, to