Rhonda Patrick

Yeah.

The other thing that came to my mind that I now remember I've heard a lot of people talk about is creatine supplementation increasing their urination, particularly during sleep, like having to go urinate frequently.

Okay.

Well, that's good to know.

I think we've covered a lot.

There's one area I did want to talk about.

And we talked about kind of saving at the end because there's more speculation here.

And this is just an interest of mine.

I remember several years ago, a former colleague of mine, Mark Shigenaga said,

um, was talking to me about, you know, creatine production in the liver being one of the biggest, biggest, um, sort of sinks for methylation.

And that's because you need, you need methyl groups to produce it.

Yes.

And as a byproduct, you also make homocysteine.

And so, um, he was talking about some, at the time, I think it was pretty preliminary, but some evidence showing that if you did supplement with creatine, that, um,

The enzymes in the liver that do produce creatine, there was a feedback, and they sensed that, and they didn't use so much of them.

The methyl groups were being shunted to other methylation pathways.

And so I'm just wondering if you've come across any evidence looking at creatine supplementation and homocysteine levels, for example?

So the question is, like, maybe you need to start with a population that has elevated homocysteine.

Because it's hard to detect small changes when you already have.

Well, maybe someone will look at it.