Saranya Wyles, M.D., Ph.D.

So usually in March, April, kids get outside, they start playing baseball or just going outside.

And we start to see these populations that do come into dermatology clinic where they're having what we call juvenile spring eruption, where they do get a little early burn.

And this goes away entirely after maybe six or seven weeks of exposure to that early spring sun.

And we do see this.

The skin has this ability to...

gain resistance over time.

And it usually, you know, in climates that are in the south or just more sun exposure throughout the year, you're going to see a lot more resistance with these kids because they're continuously getting

sun exposure throughout the year.

In contrast to kids that are kind of seeing more seasonal changes with the environment, they do have that early spring change where they're kind of needing to build up that resistance again before the summer.

So the skin is very dynamic and it does adapt to different climates in different ways.

Yeah, that's a great point about peptides because it can be really confusing.

It seems to be one of the most promising categories, but there's a lot of brands that I think overhype them, and this is where we need to filter through and see when peptides are correct.

Are they stable?

Are they bioactive?

So just defining peptides, they're just short amino acid sequences, two to 50.

Think about them as like a biological text message.

And when you have peptides for the skin, you want to think about which receptors are they going to be talking to, those signals and text messages.

So in the skin, we look at receptors like retinoids.

So, you know, topical retinoids and retin-A and tretinoin, these are nuclear receptors.

So they are really important for skin turnover and maintaining collagen elastin.