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Shana Kelley

👤 Person
179 total appearances

Appearances Over Time

Podcast Appearances

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

Yeah, well, I really appreciate, Eric, the way you summed it up.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

It's something we're very excited about too.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And you're right that this all started with glucose sensing, right?

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

It used to be if you were a diabetic, you had to go to the pharmacy to get your glucose measured.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And then you got a handheld, right?

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And that really transformed diabetes management.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

Now we have continuous glucose monitors that sit on the arm and can read glucose in real time.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

But at the core of that is a sensor.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

right, that reads out the glucose concentration.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And what's been very elusive when it comes to kind of all other analytes, especially protein analytes, is how to get that same form factor, you know, how to have an autonomous sensor that can just sit in a fluid in the human body and read out concentrations.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And so that's the problem we've been working away on for several years, many years.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And we eventually came up with a sensor that's basically like a molecular motion detector.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

It sits on the surface of an electrode and it's just kind of it's moving around.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

We use electric fields to kind of move it in a way that we can monitor.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And it turns out that when the sensor binds a protein of interest.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

That slows it down.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And so we can just watch that motion, do that over time, and quantitate concentrations of proteins in the blood or in the interstitial fluid is usually where we're making our measurements.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

Yeah, that's exactly right.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

So I have a puppy at home and we throw balls for him all the time.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

He's really good.

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