Sharon Brangman
speaker
219 appearances
2 recordings
1 series
first heard Jan 2023
last heard Aug 2023
Sharon Brangman’s voice in public audio — every appearance, attributed to the second.
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I was gonna say there's still a lot of questions about biomarkers because I don't think they've been really studied in people who aren't white.
So they are not they haven't been studied in African Americans, Asian populations.
We know that what they do in people who are um, you know, Caucasian white people, but we don't know in other groups.
So this is the nature of medicine, even beyond Alzheimer's uh drugs.
We we tend to enroll people in clinical trials who we care about.
And the other problem is is that we don't know from these trials, even the sc the skimpy numbers, who was turned away because they didn't have enough amyloid versus who wasn't even recruited in the first place.
So I think there's a lot of information that we need so that we can take care of broad groups of older adults appropriately.
And especially
Since everything is going toward making a decision based on biomarkers.
And that's going to whole groups of people excluded from formal diagnosis.
But we also don't know when the disease might present itself, because there are clearly people who have amyloid for years and they're cognitively intact.
And again, I just don't want us to forget how we've created a built-in disparity right here in making a diagnosis of Alzheimer's disease.
And I'm not sure how we rectify that until we start broadening our research base.
We're we're talking about a real small percentage of the population right now with Alzheimer's disease.
And there may be other entry points, but we're just focused on amyloid that's the only thing we've looked at.
But we're still excluding a lot of people because we do not know what amyloid looks like across different racial groups.
No, I
I would want us to weigh in on on what building this infrastructure is gonna look like and how we make it inclusive.
Thanks for having me.
Just to follow up on what Nancy said, I think the thing that's really distinct here is that it's action oriented.
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