William Parker, PhD

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154 appearances 1 recordings 1 series first heard Jul 2026 last heard 22 Jul

William Parker, PhD’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.

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And I work with...
academic neuroscientist so when you put it all together what's going on is that you're looking at a period of rapid brain development and you're putting in a chemical which in susceptible individuals is getting shunted into that toxic pathway and when you create that toxic
molecule, it's called NAPQI, it's a quinonamine, but it doesn't matter.
It's the same kind of toxic metabolite you get from alcohol.
And it's in fact the same enzyme, exactly the same enzyme that converts alcohol into a toxic metabolite that makes acetaminophen into a toxic metabolite.
So once you get the toxic metabolite, what it does is that the actual acetaminophen molecule will stick onto a protein and makes what's called an adduct.
Now, acetaminophen is pretty small and probably sticking on, say, and it usually sticks on something called a mitochondrial protein, which is the powerhouse of the cell, and it will cause mitochondrial dysfunctions.
And then there's another step.
Your body actually is trying to clean up things, and it will replace the acetaminophen molecule with a molecule called glutathione and actually stick the glutathione on the protein, which is even worse because glutathione is pretty big.
and people think of glutathione as being a safety outlet and it is but it's not it doesn't belong on a protein and then eventually you get cell death and we can measure that and uh in the laboratory animals of course you can't do that in humans for obvious reasons you can't you know this is this is injury that occurs very quickly and then of course the within uh within two to 24 hours you're looking at that injury but of course the drug is given
on a repeated basis every five to six hours for the children who are very ill and then that that's you're looking at a time where there's a lot of remodeling going on in the brain after the child reaches about the age of six the brain is too developed so they're you don't you don't see regression into autism after the age of six i mean you do you know you're seeing connections associations
between acetaminophen and autism in regression in early childhood and especially during labor and delivery.
That's the worst.
So we tell people you need to make a birth plan and during pregnancy, which is the lower level of risk.
So the most damage is probably done during labor and delivery.
So two parts of that question is, one is, does it ever have to be given to a child?
And that is not evidence-based medicine, right?
Right.
So the number one is we don't know if we should ever really be giving it, maybe occasionally for fevers during pregnancy, but we don't have any data on that.
We just don't know if that's even dangerous at all or helpful.
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