Yusuf

speaker

135 appearances 1 recordings 1 series first heard May 2026 last heard 28 May

Yusuf’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 1 in all, peaking in May 2026 with 1.

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The Clinical Problem Solvers · Episode 459 – Schema Episode: Coagulopathy · 28 May 2026 podcast

Platelet count, 500,000.

His CPK, 7,000.

Creatinine, normal.

Electrolytes, normal.

Surgery, they come and see him, take him to OR immediately.

They perform a fasciotomy.

And while performing the fasciotomy, the patient has severe oozing of blood inside the OR.

And in the OR, they review the labs, and he actually has a PT that is normal and a PTT that is markedly elevated at 80.

So they actually consult hematology from inside the OR,

And in the OR, they call him and he was like, okay, let's do some fresh frozen plasma, some tranexamic acid, some prothrombin complex, and they complete the OR safely.

So I'm going to stop there and throw it to Maddy.

Even your dog is scared of the coagulation cascade.

Wow.

Your discussion is like an expert discussion.

So you all are doing amazing.

So the patient did not have a history of bleeding prior to these events, has had procedures in the past that went well.

And hematology recommended sending the work up, like you all said.

So a mixing study

fibrinogen level, factor VIII, V, X, XIII, and von Willebrand studies, because there is a version of von Willebrand disease that causes a factor VIII deficiency, and I'll talk about that shortly after we finish the discussion.

So his factor VIII level was extremely low, almost undetectable.

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