Dr Sarah Milne - Friedreich's Ataxia & the cerebellum

This month we are chatting with Dr. Sarah Milne from Murdoch Children’s Research Institute who is also the Coordinator of the Friedreich's Ataxia Clinic at Monash Health in Melbourne, Australia. Sarah is an expert in hereditary cerebellar ataxias and after completing her PhD in 2018 she is trying to bolster the evidence base about the right rehab for people with Friedreich’s Ataxia. This episode will appeal to people treating Friedreich’s Ataxia or any of the inherited cerebellar ataxias, and to anyone who sees people with cerebellar pathology. Also of interest are the chats about challenges of rehabilitation research. The audio quality in this episode isn’t up to our usual standard with a lot of static happening – sorry!2.01 Intro & career pathway4.38 Friedreich’s ataxia7.00 How is Friedreich’s ataxia different to the hereditary cerebellar ataxias?8.36 Phenotypes in neurological conditions and the RCT paradigm11.20 PhD results   15.02 State of the Friedreich’s ataxia evidence16.49 Ataxia outcome measures 20.03 Ataxia assessment24.25 Compensation vs optimal cerebellar functioning27.00 What can imaging tell us about cerebellar conditions?29.55 Treatment 36.16 Efficacy vs Effectiveness, challenges of rehab trials 39.23 Aquatic physio for this population41.43 Episode reflectionLinksResearch GatePhD - 4 studies – Pilot rehabilitation trial for people with Friedreich’s Ataxia. Clinical audit of LL spasticity relationship with ataxia severity & function. Sensitivity of balance, gait measures and instrumented measures of gait & balance change over time.LinkedInUniversity of Melbourne profileArticles discussed:Brain Changes Associated with Postural Training in Patients with Cerebellar DegenerationHome aerobic training for cerebellar degenerative diseases: a randomized controlled trialCycling regimen induces spinal circuitry plasticity and improves leg muscle coordination in individuals with spinocerebellar ataxiaPredictors of loss of ambulation in Friedreich's ataxiaLike our podcast and want to support us? Share the show with your friends & colleagues, give us a rating on your podcast platform or Buy us a coffee. Matt & Erin run the podcast out of their own time and resources. We'd love to update our recording equipment & cover our podcast publisLike our podcast and want to support us?Share the show with your friends & colleagues, give us a rating on your podcast platform or Buy us a coffee. Matt & Erin run the podcast out of their own time and resources. We'd love to update our recording equipment & cover our podcast publishing costs. Buy us a coffee if you can.

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