In this episode, we’re joined by coauthors Preedajit Wongkrasant and Keith A. Sharkey to discuss their recent publication, "Fructooligosaccharides slow colonic motility and activate myenteric neurons via calcium sensing and 5-HT3 receptors in the proximal colon." Calcium-sensing receptors are known to play an important role in gastrointestinal physiology. This study reveals a new function of fructooligosaccharides, a type of dietary fiber, in regulating colonic motility and activating the enteric nervous system. The effects are mediated through calcium-sensing and 5-HT3 receptors, providing new insights into gut–brain communication and potential therapeutic targets for gastrointestinal disorders. Fructooligosaccharides slow colonic motility and activate myenteric neurons via calcium sensing and 5-HT3 receptors in the proximal colon Preedajit Wongkrasant, Laurie E. Wallace, Wallace K. MacNaughton, and Keith A. Sharkey American Journal of Physiology-Gastrointestinal and Liver Physiology 2025 328:6, G734-G745

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