Why Early Colostrum Feeding Matters: Insights from Dr. Valérie Verhasselt

Lactation Exam Mastery Course! Master the IBCLC Exam Today!In this episode of Behind the Latch, Margaret interviews Dr. Valérie Verhasselt, Professor of Immunology at the University of Western Australia and Head of the LRF Centre for Immunology and Breastfeeding. Dr. Verhasselt discusses her groundbreaking research on colostrum and food allergy prevention, focusing on her recent study demonstrating that partial colostrum feeding in the first 72 hours of life increases the risk of peanut allergy, while exclusive colostrum feeding appears profoundly protective. Her findings offer a powerful reframing of early postpartum lactation care: the risk may not stem solely from early cow’s milk exposure, but from reduced colostrum intake during the critical adaptation period when the newborn’s gut, immune system, and microbiota are being programmed. She explains how colostrum’s unique concentration of growth factors, IgA, vitamin A, and immune-modulating bioactive components help seal the gut, seed the microbiome, strengthen the skin barrier, and establish immune tolerance—laying the foundation for lifelong resilience. Dr. Verhasselt also shares insights from mouse models, discusses why donor mature milk is not a substitute for colostrum, and explores future directions including donor colostrum banks, colostrum-derived therapeutics, and new research on colostrum’s role in brain development. https://pubmed.ncbi.nlm.nih.gov/40968490/🔍 What We Talk AboutHow Dr. Verhasselt entered lactation immunology after a “flash” inspiration during her early research career Why the transition from intrauterine to extrauterine life makes newborns uniquely vulnerable to allergy developmentHow colostrum supports gut closure, immune regulation, microbiota seeding, and skin barrier maturationWhy giving formula in the first days displaces colostrum intake rather than simply “topping up” Evidence showing a five-fold increase in peanut allergy among infants who received partial colostrum feedingThe striking finding that no infants who received ≥9 colostrum feeds developed peanut allergy by 12–18 monthsWhat early formula exposure does to the infant microbiome weeks and months laterHow parental allergy risk influences—but does not override—the protective effect of colostrumWhy exclusive breastfeeding data often overlook the critical first 72 hoursThe interplay between infant skin permeability, environmental exposure, detergent use, and allergy sensitizationWhat mouse models teach us about colostrum, mature milk, and developmental programmingWhy donor milk does not replicate colostrum’s early immunological functionThe concept of exclusive colostrum feeding as a distinct clinical and public health priorityFuture research avenues: colostrum-derived metabolites, donor colostrum banks, and early-life allergy prevention strategies🧠 Key Takeaways for CliniciansColostrum’s immunological role is unique and time-sensitive—its composition cannot be replicated by mature milk, donor milk, or formula.Supplementation in the first days displaces colostrum volume, which may be the primary mechanism increasing allergy risk.As few as nine colostrum feeds in the first 72 hours appear profoundly protective against peanut allergy.Early formula exposure—even brief—can alter the infant gut...

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