This episode is brought to you by Cozy Earth and Pique Life. We know the seeds of Alzheimer’s are planted at least twenty years before a diagnosis. So, it’s never too early to make crucial lifestyle changes that can influence brain health and the risk of developing neurodegenerative diseases. Today on The Dhru Purohit Show, we’re bringing you a special compilation episode featuring Dhru’s conversations with leading experts on Alzheimer’s and brain health. Dr. David Perlmutter explores the key factors that influence Alzheimer’s risk and shares his top lifestyle strategies for prevention. He also discusses tools to assess brain energy usage and dives into the gut-brain connection. Dr. Mosconi explains what happens to a woman’s brain during menopause and its connection to Alzheimer’s disease. She also shares how recent research validates women's experiences in perimenopause and menopause, along with key lifestyle habits to prevent dementia and support a smoother transition. Dr. Perlmutter is a board-certified neurologist and five-time New York Times bestselling author. He is a fellow of the American College of Nutrition and serves on their Board of Directors. He has published extensively in peer-reviewed scientific journals, including the Journal of Alzheimer’s Disease, Archives of Neurology, and Neurosurgery. Lisa Mosconi, PhD, is an associate professor of neuroscience in neurology and radiology at Weill Cornell Medicine and the director of the Women’s Brain Initiative and the Alzheimer’s Prevention Clinic at Weill Cornell Medicine/NewYork-Presbyterian Hospital. She is the New York Times bestselling author of The XX Brain and Brain Food. In this episode, Dhru and his guests dive into: Genetics vs. Lifestyle: Their roles in diagnosis and impact on health (1:39) How Insulin Resistance Affects the Brain: Compromised brain energetics (04:20) Key ingredients that impact the body like sugar (11:11) Blood Sugar Game-Changers: Strategies for better management (20:14) Foods Dr. Perlmutter avoids & the gut-brain connection (27:32) The brain’s energy demands & top antioxidant-rich foods (34:32) What’s happening in the brain during menopause (38:31) Validating menopause symptoms and women’s experiences (47:32) Brain changes in perimenopause & key transitions (52:02) Why the brain is unique and why consistency is key (59:32) Also mentioned: Full episode with David Perlmutter Full episode with Dr. Lisa Mosconi This episode is brought to you by Cozy Earth and Pique Life. Right now, get 40% off your Cozy Earth sheets. Just head over to cozyearth.com/dhru and use code DHRUP. Right now, Pique Life is offering 20% off the Pu’er fermented black and green teas. Plus, you’ll get a free beaker and frother when you go to piquelife.com/dhru. Learn more about your ad choices. Visit megaphone.fm/adchoices
Full Episode
Hi everyone, Drew Proat here. Let me share some pretty sobering statistics with you. Globally, 55 million people have been diagnosed with Alzheimer's disease, and that number is set to triple by 2050. But you might be surprised to learn that only 3 to 5% of those cases of Alzheimer's disease are driven by only genetics.
The truth is that Alzheimer's disease and all cognitive decline has largely been shown in surveys all around the world to be seen as one of the scariest things that anyone could imagine happening to themselves. And I've seen this firsthand and the devastating impact that this can have on individuals and families with my own grandfather.
who I took care of while he was going through his own Alzheimer's diagnosis. But we know now that there is so much more that can be done to support our brain health, as well as reduce our risk of developing Alzheimer's disease and dementia.
And in today's compilation episode, I'm talking with board-certified neurologist and best-selling author, Dr. David Perlmutter, about the crucial role of blood sugar regulation in preventing Alzheimer's disease. I'm also speaking with Dr. Lisa Moscone, an associate professor of neuroscience in neurology and radiology at Cornell Medicine.
and the director of the Women's Brain Initiative and the Alzheimer's Prevention Clinic at New York Presbyterian Hospital. Dr. Moscone and I talk about the impact of glucose metabolism on brain health, particularly in menopause. But first, let's dive into my conversation with Dr. David Perlmutter.
Give us the next big bucket that you often see for people that often doesn't get as much attention as diet does when it comes to cognitive decline, dementia, and Alzheimer's.
I'd say that first as a counter to the notion of what are the big legs that support this decline would be genetics. Genetics is not that relevant. In fact, playing only about a 5% role that people say, well, I carry the APOE4 allele, therefore I'm at greater risk. But understand that that so-called Alzheimer's gene plays upon other variables that we can absolutely control.
So, you know, the point I want to make for your viewers is really quite simple. And that is if mom or dad had Alzheimer's, or if you know that you, by virtue of your 23andMe or other genetic profile, carry one or two of what are called the APOE4 alleles, which are indeed associated with increased risk for Alzheimer's, All well and good and interesting.
No question that having that genetic predisposition and others, presenilin-1, for example, increase your risk. But by all means, the dye isn't cast. It means that our choices, we have control over things that are really influential. And
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