In this episode, Dr. Jockers sits down with neurologist and bestselling author Dr. David Perlmutter to explore microglia, the brain's immune cells, and the role they may play in protecting the brain from cognitive decline. You'll learn what can shift these cells from a supportive state toward one that promotes neuroinflammation. Discover why your metabolic health and brain health are deeply connected. Dr. Perlmutter explains how blood sugar, insulin resistance, gut health, and chronic inflammation can influence microglial function and why addressing these factors may be important long before memory problems appear. You'll also hear practical ways to support your brain through exercise, nutrition, sleep, metabolic flexibility, and other daily habits. Dr. Perlmutter shares why protecting your brain isn't just about what happens later in life—and how the choices you make today can help shape your cognitive future. In This Episode: 00:00 Amyloid Myth Busted 00:15 Show Intro and Guest 04:18 Book Inspiration Microglia 06:02 Symptom Care vs Root Cause 09:51 Microglia M1 vs M2 11:15 Gut Brain Inflammation Link 15:01 Metabolism Mirrors Microglia 17:57 Infections Vaccines and Triggers 19:31 CTE Diabetes and Feedforward 25:20 New Tools and Beta Amyloid Drugs 30:37 Cochrane Verdict Drugs Fail 33:28 Lifestyle Trial Reverses Decline 38:23 Microglia Lifestyle Levers 39:07 Exercise Myokines Brain Boost 42:20 Alzheimers Risk Epigenetics 45:12 Imaging Microglia TSPO 46:24 Fasting Ketones Brain Fuel 49:45 MCT Oil Memory Care 51:16 POINTER Lifestyle Trial 55:57 Fiber Polyphenols Foods 58:34 Supplements DHA Vitamin D 01:02:23 Key Labs Glucose Tau 01:06:19 Prevention Mission Wrap 01:07:43 Final Thanks Outro Enjoy a clean, protein-packed snack with PaleoValley's Grass-Fed Beef Sticks. Made without sugar, additives, or preservatives, they're packed with healthy fats and grass-fed nutrients to help curb cravings, support steady energy, and keep you satisfied on the go. Save 15% with code DRJOCKERS at paleovalley.com/drjockers. Give your hair and skin routine an upgrade with iRestore's advanced red light therapy devices. The iRestore Elite combines 300 lasers and 200 LEDs to support thicker, healthier-looking hair, while the cordless Illumina Face Mask uses triple-wavelength light therapy to target fine lines, breakouts, and dullness. Take advantage of iRestore's Labor Day savings and huge discounts at iRestore.com and use promo code DRJOCKERS to save. Stop guessing about your health and start understanding what's happening inside your body with Superpower Health. One simple blood draw measures 100+ biomarkers covering your heart, liver, thyroid, hormones, metabolism, vitamins, minerals, and environmental toxins, plus you'll get ongoing tracking and access to a clinician team. Head to Superpower.com and use promo code JOCKERS to get $20 off your membership for a limited time. Support your joints, hair, nails, skin, and recovery with BUBS Naturals Collagen Peptides, a tasteless, odorless formula that mixes easily into coffee, smoothies, or juice. It has zero sugar, sweeteners, or fillers and is third-party tested, NSF Certified for Sport, Whole30 Approved, and sustainably sourced from grass-fed, pasture-raised cattle. Head to BUBSNaturals.com and use promo code DRJOCKERS to get 20% off for a limited time. "Exercise isn't just changing your body. It's changing the environment inside your brain." Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio Resources: Enjoy 15% off grass-fed beef sticks with code DRJOCKERS at paleovalley.com/drjockers. Go to iRestore.com and use promo code DRJOCKERS Visit Superpower.com and use promo code JOCKERS to get $20 off Visit BUBSNaturals.com and use promo code DRJOCKERS to get 20% off Connect with Dr. David Perlmutter: Book - https://a.co/d/06cRZKlT Website - https://drperlmutter.com/ Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

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“What did the council decide on item 42?” — answered with the speaker and the moment.

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