What if perimenopause isn’t only changing your hormones, but also changing how your body is aging underneath the surface? In this episode, Dr. Mariza sits down with Nikolina Lauc, CEO and co-founder of GlycanAge, to explore emerging research on immune aging, chronic low-grade inflammation, and the menopause transition. Nikolina shares research showing just how dramatically markers of “inflammaging” can shift when estrogen declines. In one hormone-blocking study, women gained 9.1 years on GlycanAge markers within six months, while research following twins found the rate of immune aging accelerated during the transition from perimenopause to menopause. They unpack why this inflammation may be happening even when your traditional labs look normal, what glycans can reveal about how your immune system is functioning, and why biological age is more complex than a single number. They also explore the research around HRT, exercise, weight loss, fasting, GLP-1 medications, nutrition, and why the same intervention doesn’t work the same way for every woman. Listen now to discover what may be happening beneath the surface in perimenopause and how better data could help you become more proactive about how you age. NIKOLINA LAUC Nikolina Lauc is the CEO and co-founder of GlycanAge, a longevity biotechnology company focused on glycans, immune aging, chronic inflammation, and biological age. GlycanAge’s research focuses specifically on “inflammaging,” the chronic, low-grade systemic inflammation associated with aging. Its work examines glycan structures on antibodies to better understand whether the immune system is behaving in a more pro-inflammatory or anti-inflammatory way. IN THIS EPISODE What biological age actually means and why there isn’t one universal biological-age number How chronic low-grade inflammation can develop without obvious symptoms Why immune-aging markers may accelerate during the menopause transition How declining estrogen influences inflammation and immune function Why your hormone and traditional inflammatory labs can look normal while something is shifting What glycans can reveal about your immune system and inflammaging What the research suggests about HRT, exercise, weight loss, fasting, and GLP-1s Why interventions for healthy aging need to be personalized QUOTES “There’s never going to be one biological age.” “Not everybody experiences perimenopause in the same way.” “There’s no universal diet.” RESOURCES MENTIONED Use Code ENERGIZED and Get 10% Off on your GlycanAge Single Order or Subscription https://www.glycanage.com/dashboard/shop GlycanAge Website GlycanAge Instagram GlycanAge LinkedIn RELATED EPISODES 771: Beyond Hot Flashes: The 103 Symptoms of Perimenopause No One Talks About with Andrea Donsky 770: The Heart Disease Risk Factor Most Women Aren’t Watching: What Your Blood Sugar and Insulin Can Reveal with Dr. Philip Ovadia 769: Is It Perimenopause or Something Else? How to Finally Connect the Dots with Dr. Mariza 750: The Underlying Cellular Cause of Midlife Fatigue, Brain Fog & Low Motivation with Andrew Salzman

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