Ep. 496 We Got Brain Health All Wrong – The Shocking Link Between Inflammation, Stress & Aging with Dr. Austin Perlmutter | Brain Health & Metabolic Health

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Previously titled “Ep. 496 We Got Brain Health All Wrong – The Shocking Link Between Inflammation, Stress & Aging with Dr. Austin Perlmutter” — renamed by the publisher on Aug 3, 2026

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Recorded30 Aug 2025

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Show notes

Today, I am thrilled to connect with Dr. Austin Perlmutter, a board-certified internal medicine physician, New York Times bestselling author, researcher, educator, podcaster, and entrepreneur. He is on a mission to help people get their brains unstuck for better mental and cognitive health. In our conversation today, we explore brain inflammation and its connection to longevity, the differences between acute and chronic inflammation, the influence of environmental factors, and how exposure to negative news and biases can elevate stress and affect our brain health. We examine how consumer culture promotes stress and disconnection, and we unpack the immune-metabolic effects of estrogen and its impact on neuroplasticity and our ability to learn. We also focus on the role of nutrition and nutraceuticals, and we discuss the relationship between the brain, gut, and the vagus nerve. This discussion with Dr. Austin Perlmutter is rich and insightful, and I look forward to welcoming him back for further exploration into the science and research. IN THIS EPISODE, YOU WILL LEARN: Why brain inflammation becomes an issue for many women as they navigate middle age and beyond How inflammation leads to constant changes in our cognitive and mental state Various environmental factors and other inputs that could influence brain inflammation Some easy ways to positively impact your brain health and cognition How chronic stress affects the brain How the gut microbiome and the gut immune system influence cognitive and mental health The long-term health benefits of avoiding processed foods and following a Mediterranean diet The importance of being conscientious and purposeful about the quality of the foods you eat Dr. Perlmutter shares easy and cost-effective ways to improve your cognitive, mental, and overall health Bio: Dr. Austin Perlmutter is a board-certified internal medicine physician, New York Times bestselling author, published researcher, and a leading expert on how lifestyle and environmental factors impact mental health. His mission is to help people reclaim their mental and physical health by addressing the biological basis of “stuckness” that disrupts brain function and emotional balance. He is a co-producer of the Alzheimer’s: The Science of Prevention series and the host of the Better Brain Blueprint series, where he provides actionable strategies to support brain resilience. Dr. Perlmutter currently serves as the Managing Director at Big Bold Health, a food-as-medicine company focused on helping people rejuvenate health through better immune function, where he has published a pioneering study exploring the effects of plant nutrients on human aging through epigenetics. Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Austin Perlmutter On his website On social media: @draustinperlmutter Find out more about the research on immuno-metabolism pathways Big Bold Health on social media: @bigboldhealth

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