Show notes
I’m thrilled to reconnect with microbiome expert Kiran Krishnan today. Kiran co-founded Just Thrive and previously served as Chief Scientific Officer at Microbiome Labs. He has more than 16 years of experience in the dietary supplement and nutrition industry, with postgraduate research experience in molecular biology and virology.
In today’s conversation, we take a deep dive into the science of spore-based probiotics, their ecological impact, how they interact with the existing gut microbiome, their potential to address dysbiosis, and why standard probiotics fail to survive stomach acid in meaningful numbers. We explore research on osteoarthritis, catabolism, and the gut-hormone connection, discussing how declining bacterial diversity may influence the metabolic and hormonal changes associated with perimenopause and menopause. Kiran explains the role of the pathobiome and endotoxemia, how the gut-brain axis can influence inflammation, and the importance of gut-barrier integrity, neurotransmitter production, and vagal nerve signaling in regulating the immune system. We also discuss the differences between fiber, resistant starch, polyphenols, fermented foods, prebiotics, and postbiotics, and Kiran shares his perspective on the carnivore diet, its potential impact on the microbiome, and key insights into SIBO.
Stay tuned for today’s fascinating and informative conversation with Kiran Krishnan.
IN THIS EPISODE, YOU WILL LEARN:
Kiran explains the science behind spore-based probiotics
Why spore-based probiotics can survive stomach acid better than many standard probiotics
How inflammation can inhibit the growth of beneficial gut bacteria
How bacterial diversity in the gut decreases during perimenopause and menopause
Why awareness of endotoxemia remains limited within the broader medical community
Kiran explains how the gut-brain axis helps the body respond to its environment
What prebiotics and postbiotics actually do
Why an inability to tolerate fiber may point to a problem with the underlying biology rather than the food itself
How SIBO and SIFO can be symptoms of a more complex underlying problem
Bio: Kiran Krishman, Ph.D.
Kiran is a research microbiologist and a health and wellness expert who aims to make complex information understandable to all. He has founded several successful health and supplement companies over the last 15 years, including co-founding and leading Microbiome Labs, a preeminent microbiome therapeutics-focused brand among healthcare professionals. He is currently a co-founder and partner in 3 other companies that aim to revolutionize wellness care. He has conducted and published several research studies in scientific journals, published chapters in scientific textbooks/references books, holds global patents, and is a sought-after speaker on human health and the microbiome.
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