LATE vs Alzheimer's: Biomarkers, Mixed Dementia, and Clinical Realities with Nate Chin & Sterling Johnson
episode
GeriPal - A Geriatrics and Palliative Medicine Podcast
45 min
2 speakers
4 chapters
transcribed 10 hours ago
Transcript
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Transcript generated automatically by AI and may contain errors.
What is the main topic discussed in this episode?
This podcast is not C Me Eligible. If people do want to learn more about C Me Eligible Podcasts, Alex, what do they do?
They can go to JerryPal.org backslash CME.
And on to the show. Welcome to the JRPel podcast is Eric Widera. This is Alex Smith. And Alex, we we got a really interesting topic today. We're gonna be talking about something called late. Have you ever heard about late before? I
have
not
heard of
late.
Am I late?
Yeah, you're late to the late maybe you're not too late. Late and mixed dementias, how do we think about them when we're thinking about cognitive impairment? And who are our guests for this episode?
We are delighted to welcome back third time guest, Nate Chin, who is a geriatrician and medical director of the Alzheimer's Disease Research Center at the University of Wisconsin. Welcome back, Nate. Thanks for having me. He's also author, we should say, of a book, When Memory Fades recently out, right? Like last month. Yep. And we'll have a link to that in our show notes. What's
that about, Nate? It is the story of my own experience with my father's early onset Alzheimer's mixed in with what do you do when you worry about your own loved one who's having thinking changes and then bringing in the science and the research that we'll be talking about today.
Terrific. Look forward to reading that. We hear there might be a mention of Jerry Powell in the book. Oh, then all of our listeners. Chuck that out to your listeners. Check it out. We'll have a link to that in the show notes. We're also delighted to welcome Sterling Johnson, who is a clinical neuropsychologist and dementia researcher at the University of Wisconsin, and also the principal investigator of the clarity study of mixed dementias. Welcome, Sterling, to the Jerry Powell podcast. Thank you, Alex. It's great to be here.
Who are the guests and what is the CLARiTI study they lead?
And Sterling, I think you have the song request for Alex, is that right? I do, Eric. Um I chose
Blue Sky by the Allman Brothers.
Why did you choose this song?
Well, it's it's uh first of all, one of my favorite songs. Uh always uh has been for most of my adult life as a guitar hobbyist. But also it has relevance to today, to what we're talking about. Uh blue sky, let's see if we can make this stretch. Is that's where we want to be in the diagnostic space. We want clarity uh to our patients. What what diseases do they have? They have? How much of Alzheimer's do they have? How much TDP43 do they have? So we want that clarity that a blue sky forts. So that's why I chose that song. How d how was that?
That's great. That's great. Let's hear it, Alex.
Walk along the river. Sweet lullaby. It just keeps on flowin' it don't worry about where it's going. No no Don't fly mister Bluebird, I'm just walking down the road. Early morning sunshine, tell me all I need to know. Mm. You're my blue sky, you're my sunny day. Lord, you know it makes me high when you turn your love my way. Turn your love my way.
Great song. Well done, Alex.
Yeah, fun song.
That's a tough one.
Oh, the guitar on that is amazing. People should listen to the original. It is incredible. And there's some good covers on YouTube, actually on uh acoustic guitars that do justice to the solos. Yeah. Amazing choice. Thank you, Sterling, for that. Thank you. That was amazing.
So certainly you're the PI for the Clarity Study. Uh what is the Clarity Study?
Clarity is spelled with an I at the end. It's the consortium uh across the ADRCs to bring clarity to diagnostics in um the neurodegenerative space. So what we're trying to do in clarity is understand Which of our patients have what proteinopathy in their brain? We know Alzheimer's is you you can almost um rely on that being present for for our patients that come to us with memory complaints, but not always. And sometimes they're the the things that go wrong in their brain are related to TDP forty three, which we'll talk about today. Sometimes it's alpha-sinuclein proteinopathy, which is commonly the culprit in Louis body disease and Parkinson's disease. I know we're already getting into terminology weeds, but that's the idea of clarity is to bring some clarity to the diagnostic picture for our patients and to provide the tools for that.
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Chapters
4 chaptersSpeakers
2 identifiedMore from GeriPal - A Geriatrics and Palliative Medicine Podcast
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