Episode 440: The Hidden Benefits of GLP-1s: More Than Just Weight Loss Medication
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What are GLP-1s and how do they function in the body?
Let's start with what GLP-1 is. It's a peptide. So it's a string of amino acids linked together by peptide bonds. So it's a peptide. We make GLP-1 in our bodies naturally in our brain and in our guts. We have receptors for GLP-1s all over our body that do a whole lot of different things. It just was serendipitous that it got figured out for type 2 diabetes. It does a whole lot of other things in the body. And this was really interesting to me when I started studying it. It's a peptide in that it's in and out of the body very quickly. So the body produces it and the half-life is very short. The pharmaceutical version has been tinkered with so that the half-life is much longer. So the half-life is maybe four to seven days. So that's it.
It's bioidentical. At least Ozempic, which is semaclutide, is bioidentical to our own GLP-1 for the most part. And about a year ago, I started finding literature outside of what most people understand it for. Most people understand it for reducing appetite because it plays on the centers of our brain that control appetite, for slowing gut motility so you feel fuller longer. And that's kind of where the story ends. That's kind of where people understood how it works. And that's why it's a weight loss drug. And that's why it's for type 2 diabetes. It has multiple impacts on our metabolic health in a myriad of ways that have a lot more to do than just that. And there are receptors in our brains, in our heart, in our pancreas, in our immune cells.
What are the potential health benefits of GLP-1s beyond weight loss?
And I started finding literature that was really, really interesting about this, and I started going on podcasts and sharing about it and finding information. Recent studies have come out showing significant reduction in all-cause mortality for those who are on it, reduction in different types of cancers. Cancers? colon cancer specifically, this was correlative, not causative, but they were comparing people on semaclutide versus, or even some of the other GLP-1s for a period of time versus, I think, insulin. And not a great, I mean, it's not a super clear comparison because insulin is pro-grow, so insulin can cause problems in and of itself. But interesting data coming out there recently, 13 different types of, potentially reducing 13 different types of obesity-related cancers in And then I was finding data and sharing out about potential protection against COVID and upper respiratory illness. And I was sharing about it on podcast thinking, well, if anything, I'm helping big pharma sell their peptides.
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Chapters
6 chapters
1
What are GLP-1s and how do they function in the body?
1:58–3:16
2
What are the potential health benefits of GLP-1s beyond weight loss?
3:16–4:14
3
Why is there controversy surrounding the use of GLP-1 medications?
4:14–5:24
4
How do personalized microdoses of GLP-1s work?
5:24–6:45
5
What are the implications of GLP-1s on neurological health?
6:45–7:50
6
How has the FDA's regulation affected access to peptide treatments?
7:50–12:03
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