Episode 575: Dr. Jonathan Schoeff: Peptides and the Marketing Behind Modern Longevity - Part 2
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What is the main topic discussed in this episode?
Hi, guys. It's Tony Robbins. You're listening to Habits & Hustle. Crush it. Welcome to the Habits & Hustle podcast, where I sit down with the world's biggest thinkers, entrepreneurs, athletes, and experts to uncover the habits, strategies, and mindset shifts that actually move the needle. in your health, happiness, and success. And today, I'm back with Dr. Jonathan Sheff, a surgeon, longevity expert, and co-founder of the Longevity Lab, who is still very actively practicing medicine, I should say. After part one, we knew there was a way too much left over that we had to keep on going. So in this part of the conversation, we get into this stuff everyone is talking about, but very few people actually understand, which is...
GLP-1s, muscle loss, fasting, testosterone, biomarkers, grip strength, movement, sleep, longevity metrics, which are actually worth paying attention to. What I love about Dr. Jonathan is that he does not make health more complicated to sound smart. He breaks it down in a way that makes you question the trend, understand the mechanism, and come back to the basics that actually moves the needle. What he shares in this episode will change the way you think about GLP-1's fasting, muscle, and health markers that you should actually be tracking. So let's dive in. Enjoy.
Yeah, no matter what. Are they all Skin Better that you like?
I do like the Skin Better formulations. I know it's goofy.
Why is it goofy? It's not goofy.
Oh, well, because as a guy.
As a guy, yeah. Well, you're like very, you know, you take care of yourself.
Well, I'm taking care of. That's how it works. Okay, well, either way.
I do what I'm told. Okay, listen. I do what I'm told. Well, it's working. Okay, now we can get into the GLP-1 stuff. Okay, let's do it. So you said that redditrutide is, you want any of these GLPs?
Life-changing, no. I've used all of them.
You have used all of them.
Absolutely. Well, simaglutide and up. So simaglutide, terzepatide, redditrutide. I've used all of them.
So if people are having like, so between trisepatide and retitrutide, I know one works on two receptors. One works on three receptors. So you believe it's a tool and you don't believe everyone should be on them. Even though you're talking about the insulin resistance and to build muscle. So here comes the contradiction, right? Totally. So if muscle is the biggest longevity organ to keep your insulin low, yet GLP-1s have been obviously known to like break down muscle and eat away at your muscle.
They've been blamed. They've been alleged.
Alleged. Alleged. Yes.
Let's use that.
Okay. So you don't think that the GLP-1- It's not that simple.
No, no. Well, I mean, I know the data. Okay. So if you look at the STEP1 trial, which was the first semaglutide weight loss trial, 2021. Okay. What did it demonstrate? This is really important. 40% loss of lean body mass, LBM. So the problem is, and I just saw a post on this just the other day, lean body mass is not skeletal muscle. They're not the same thing. The 40% is lean body mass. So if you want to make the argument, or say you're a personal trainer and you want to get your hustle, or you want to do some peptides, this, that, and the other, then you say, oh my gosh, 40% loss of skeletal muscle. No, it's lean body mass. And realize that lean body mass includes skeletal muscle as one component. In healthy, fit individuals, that may reach the 50% mark.
In other words, 50% of your lean body mass in a very fit, well-muscled individual can be skeletal muscle. That's in a really fit person. So it goes down from there. In other words, no one lost 40% of their muscle. That's not reality. So it's lean tissue. So it includes fat mass, but it also includes organ mass. So non-alcoholic fatty liver disease, which is what read of True Tide, 100% reduced their fatty liver, which is, that's a game changer from a health perspective. In that case, that's a part of lean body mass. So losing, improving the metabolic function of your liver, losing liver fat is a very good thing. that's lean body mass too so it's just not as clean as you know ozempic chews up muscle okay now i do agree that early on and this was the age-old story with any drug misuse and abuse that's always what brings it down so yes when personal trainers and nurses and all these people were handing out ozempic without any any clarity any reason bear in mind ozempic's like an anorexic's best friend i mean it was abused
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Chapters
4 chapters
1
What is the main topic discussed in this episode?
0:01–6:44
2
How nuanced are GLP‑1 drugs and do they always cause muscle loss?
6:44–20:15
3
Can strategic fasting preserve muscle while maximizing fat loss and repair?
20:15–28:02
4
What is the science behind AMPK, mTOR and why does fasting matter?
28:02–1:42:01
Speakers
2 identifiedMore from Habits and Hustle
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