Antipsychotic medications can be transformative for people with schizophrenia, but they come with side effects.Weight gain and metabolic dysfunction are common, and contribute to people with schizophrenia having a higher mortality than the rest of the population.A trial out of Queensland has looked at whether semaglutide might help address this weight gain, making antipsychotic medications more tolerable.Guest/sProfessor Dan Siskind, psychiatrist at the University of Queensland and metro south healthReferencesEfficacy and safety of semaglutide versus placebo for people with schizophrenia on clozapine with obesity (COaST): a phase 2, multi-centre, participant and investigator- blinded, randomised controlled trial in Australia

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