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Modern Wisdom

Mostly Wise: Matt McCusker, Andrew Huberman & Tom Segura - #1102

25 May 2026

Transcription

Chapter 1: Should all men be taking erectile dysfunction medication?

0.031 - 5.7 Chris Williamson

I keep seeing tweets about how everyone should be taking erectile dysfunction medication. Is that true? Low-grade, whatever.

0

5.72 - 20.845 Unknown

Yeah, like the low-grade. So, Tadalafil, which is the generic name for Cialis, was developed first as a prostate health drug. And then people took more of it and realized that at higher dosages, it can be effective for erectile dysfunction.

0

20.865 - 22.468 Chris Williamson

But low dose is good for prostate health.

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Chapter 2: What are the non-sexual benefits of tadalafil?

22.488 - 38.272 Unknown

Low dose, like 2.5 to 5 milligrams per day. is very helpful for perfusion of the prostate. And also it causes vasodilation in the brain. So things like strokes, I mean, you want blood flow, right? You don't want excessive blood flow where you've got a headache from it.

0

38.292 - 53.572 Unknown

But our chair of male sexual health and urology at Stanford, Mike Eisenberg, he came on the podcast and he said, pretty much every male over 40 or so should be taking about 2.5 to 5 milligrams per day. Does it still get you pretty hard too? It definitely will improve. Just curious.

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54.333 - 76.335 Unknown

It will definitely, um, it will definitely notch up like erectile strength, but unlike, you know, some health people out there, I'm not like using the calipers to measure the strength. I asked someone else to measure and, and, and, and she tells me that like, you know, not, you know, it's all good. I know what you mean.

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76.355 - 78.857 Tom Segura

Yeah. Close her hand, close her hand if you can.

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78.837 - 95.428 Unknown

Well, no, I've never actually I've never actually subjected to the grip test. You know, I don't want to tempt anybody. But in all seriousness, you know, the drug, this drug that was developed for vasodilation, which is now used for erectile dysfunction, it really was developed first as a prostate health drug.

95.408 - 111.445 Unknown

And a lot of sitting, the prostate's weird too because it doesn't get a lot of blood flow compared to other tissues. It doesn't have the same immune system. Yeah, well. What if you sit with the plug in? You're kegeling all day. So, you know, we realized, you know, Chris had to pull up to this little piece of tape so we didn't catch him kegeling over the desk.

Chapter 3: How does Retardmaxxing change perspectives on life hacks?

112.627 - 114.549 Unknown

You know, kegeling, kegeling.

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114.809 - 129.872 Chris Williamson

I kind of feel like it could just be a sigh up to normalize erectile dysfunction medication by dudes that have got erectile dysfunction. And by doing that, every man should be taking it, that nobody is then on the outside. That's fair. I take the six, it's like five to six milligrams in the morning.

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130.433 - 131.575 Unknown

You do in the morning?

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131.595 - 136.444 Chris Williamson

Yeah, every morning. There you go. What's a little troch, what's a little mint? Is that half?

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136.764 - 137.986 Unknown

What's like a- Oh, I don't know.

138.127 - 150.03 Chris Williamson

I mean, you can get- Is that a full one or a half one? Of what? The Tadalafil. Well, I'm saying it depends on the prescription that you're given, right? So like the six milligram thing is supposed to be for prostate health.

Chapter 4: What are the risks of recreating your ex with AI?

150.47 - 158.406 Chris Williamson

But if you were like to get 25, 50, obviously that's like massive blood flow and you're going to take note.

0

158.386 - 168.683 Unknown

And it can drop blood. Strong gust of wind. And it can, and it can disrupt, you know, lower blood pressure slightly and things like that. Cause you, you gain vasodilation. So, you know, all the pipes are getting a little bigger.

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169.264 - 169.845 Chris Williamson

Yeah.

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169.905 - 173.211 Unknown

So, but let's all take one right now and see like how the podcast goes.

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173.231 - 174.774 Chris Williamson

Whoever gets the erection last wins.

174.794 - 176.336 Unknown

Yeah.

176.537 - 177.218 Chris Williamson

I have a strong mind.

179.421 - 199.193 Unknown

This is not the podcast I signed up for. But to your point, it probably does feel safer for guys to call up their doctor and go, hey, I heard this podcast. I heard some MD, PhD from Stanford, not me, but Mike Eisenberg said that I should be getting better perfusion in my prostate and I should take 2.5 to five milligrams of Tadalafil.

199.173 - 215.6 Unknown

and there they just avoided all the statements about Cialis, ED, da-da-da, da-da-da. And then they call another doctor and get a duplicate prescription and now they're taking double. You can assume that some of that happens, but it's also costs like pennies. It's generic now, the patent is out.

Chapter 5: What are the psychological effects of cannabis use on young adults?

4740.491 - 4755.331 Unknown

Then they'll go back and forth, which just tells me one thing. Right. Because the right side does this, too, which is that they have no heart. They have no stance. Right. Right. It's all just algorithmic ping pong. Blow with the wind. Yeah. So the reality is some people should use cannabis if they want to.

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Chapter 6: How does sleep deprivation impact mental health?

4755.391 - 4772.993 Unknown

No problem. But I hear from lots of in particular moms of guys are in their 20s who including some people who are doing very well in life and now their kids are like in full blown psychotic episodes that won't reverse. And it's very hard to know who that's going to be. Right. But certainly there are people who can use cannabis. No problem.

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4772.973 - 4792.336 Chris Williamson

Well, even if it's not, oh, it's caused some long-term psychosis problem for me, it's not exactly a performance enhancer. This happened, I think, in the 1700s or the 1600s when coffee houses first started in Britain. And because people used to go and drink ale all day, They're just fucking drunk and wasted.

0

Chapter 7: What are the risks of extreme endurance events?

4792.436 - 4805.696 Chris Williamson

You're not going to get anything done when you're wasted. And then coffee comes along and people are like, what's all of this fucking productivity I've got in front of me? And it's kind of the same. You go, well, cannabis, no one's died from overdosing on THC apart from, I don't know, you get into a car, you fall down some set.

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4805.716 - 4813.596 Unknown

There's no road rage from caffeine. Well, I mean, there's road rage from caffeine, but no one's coming home and like beating up their spouse because they drank too much coffee. I could be the first.

0

4814.937 - 4815.938 Chris Williamson

Dude, I got to show you this video.

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4815.958 - 4817.72 Tom Segura

You seem pretty mellow. I get mean.

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Chapter 8: How does nostalgia influence our perception of past decades?

4817.8 - 4821.744 Tom Segura

No, if I have enough, my wife's bad. Have you ever seen the video of when- You're definitely drinking coffee.

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4821.764 - 4829.693 Chris Williamson

Drink driving ban. Drink driving got introduced in the US. Just no drinks at all? Yeah, so watch this. That's bullshit, bro.

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4829.713 - 4832.155 Tom Segura

Get out of here. Watch this.

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4832.215 - 4836.78 Chris Williamson

Oh, yeah. Drinking and driving here is viewed by some as downright undemocratic.

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4836.76 - 4848.422 Unknown

It's kind of getting common is when a fella can't put in a hard day's work, put in 11, 12 hours a day, and then get in your truck, and the leaser ain't one or two beers. They're making it laws where you can't drink when you want to.

4848.663 - 4849.825 Chris Williamson

Baby in the passenger seat.

4849.845 - 4854.85 Unknown

You have to wear a seatbelt when you're driving. We're going to become this country.

4854.87 - 4858.253 Chris Williamson

Hell yeah. Unreal. Just the fucking best.

4858.654 - 4866.841 Tom Segura

I will say, if you had worked outside all day for 11 hours, you can drink one beer on your way home. That's fair. One ice cold beer anywhere.

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