Neurology Minute
Episodes
Treatment of Multiple Sclerosis: Part 2
23 Aug 2022
Contributed by Lukas
In part 2 of a 3-part series, Anne Cross, MD, FAAN, discusses her article, "Treatment of Multiple Sclerosis" from the Continuum August Multiple Sclero...
Treatment of Multiple Sclerosis: Part 1
22 Aug 2022
Contributed by Lukas
In part 1 of a 3-part series, Anne Cross, MD, FAAN, discusses her article, "Treatment of Multiple Sclerosis" from the Continuum August Multiple Sclero...
Histiocytic Diseases Affecting the Central Nervous System
19 Aug 2022
Contributed by Lukas
Dr. W. Oliver Tobin discusses histiocytic diseases affecting the central nervous system. This podcast is sponsored by argenx. Visit www.vyvgarthcp.c...
Predicting Outcomes Among Patients Undergoing Intracranial EEG
18 Aug 2022
Contributed by Lukas
Dr. Adithya Sivaraju discusses the Neurology article, "Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refra...
Myelin Oligodendrocyte Glycoprotein–Associated Disorders - Part 3
17 Aug 2022
Contributed by Lukas
In part 3 of a 3-part series, Erin Longbrake, MD, Ph.D., FAAN, discusses her article, "Myelin Oligodendrocyte Glycoprotein–Associated Disorders" fro...
Myelin Oligodendrocyte Glycoprotein–Associated Disorders - Part 2
16 Aug 2022
Contributed by Lukas
In part 2 of a 3-part series, Erin Longbrake, MD, PhD, FAAN, discusses her article, "Myelin Oligodendrocyte Glycoprotein–Associated Disorders" from ...
Myelin Oligodendrocyte Glycoprotein–Associated Disorders - Part 1
15 Aug 2022
Contributed by Lukas
In part 1 of a 3-part series, Erin Longbrake, MD, PhD, FAAN, discusses her article, "Myelin Oligodendrocyte Glycoprotein–Associated Disorders" from ...
Young-Onset Ischemic Stroke Risk Factors in Black and White Individuals
12 Aug 2022
Contributed by Lukas
Dr. Prachi Mehndiratta discusses the differences in multiple risk factors between Black and White individuals with young-onset ischemic stroke. Sh...
Perceptions vs Experience for Patients Undergoing Lumbar Puncture
11 Aug 2022
Contributed by Lukas
Dr. Adrienne Boire discusses her paper from Neurology Clinical Practice, " Discordance between perceptions and experience of lumbar puncture: A pros...
Diagnosis of Multiple Sclerosis - Part 3
10 Aug 2022
Contributed by Lukas
In part 3 of a 3-part series, Jiwon Oh, MD, Ph.D., FRCPC, discusses her article, "Diagnosis of Multiple Sclerosis" from the Continuum August Multiple ...
Diagnosis of Multiple Sclerosis - Part 2
09 Aug 2022
Contributed by Lukas
In part 2 of a 3-part series, Jiwon Oh, MD, Ph.D., FRCPC, discusses her article, "Diagnosis of Multiple Sclerosis" from the Continuum August Multiple ...
Diagnosis of Multiple Sclerosis - Part 1
08 Aug 2022
Contributed by Lukas
In part 1 of a 3-part series, Jiwon Oh, MD, Ph.D., FRCPC, discusses her article, "Diagnosis of Multiple Sclerosis" from the Continuum August Multiple ...
Alpha-Synuclein Amplification for Disease Diagnosis
05 Aug 2022
Contributed by Lukas
Dr. Lucilla Parnetti discusses the clinical application of α-synuclein seed amplification assays (SAAs) in the identification of Parkinson's disease...
The WHO Brain Health Unit
04 Aug 2022
Contributed by Lukas
Dr. Nicoline Schiess discusses the WHO Brain Health Unit and the Intersectoral Global Action Plan for Epilepsy and Other Neurological Disorders. This...
Racial, Ethnic Disparities in Multiple Sclerosis Prevalence
02 Aug 2022
Contributed by Lukas
Dr. Rae Bacharach discusses the Neurology article, "Racial and Ethnic Disparities in Multiple Sclerosis Prevalence". Show references: Racial and Eth...
Chronic Headaches and Warning Signs
01 Aug 2022
Contributed by Lukas
Dr. Tesha Monteith discusses chronic headaches from the June NeuroPanels webinar. Show references: https://learning.aan.com/diweb/catalog/item?id=927...
Adverse Childhood Experiences and Neurologic Conditions
29 Jul 2022
Contributed by Lukas
Dr. Rae Bacharach discusses the Neurology Today article, "Adverse Childhood Experiences May Underlie Neurologic Conditions A Call to Action for Aware...
Genetics and the Age-at-Onset in Parkinson's Disease
28 Jul 2022
Contributed by Lukas
Dr. Manu Sharma discusses his paper, "Genome-wide Association and Meta-analysis of Age-at-Onset in Parkinson's Disease: Evidence From COURAGE-PD Cons...
Recurrence of TGA
27 Jul 2022
Contributed by Lukas
Dr. Micaela Hernández discusses her article, "Transient Global Amnesia Recurrence: Prevalence and Risk Factor Meta-analysis". Show references: https:...
Continuum: Cognitive Syndromes Associated With Movement Disorders - Part 2
26 Jul 2022
Contributed by Lukas
In part 2 of a 2-part series, Jennifer G. Goldman, MD, MS, FAAN, discusses her article, "Cognitive Syndromes Associated With Movement Disorders" from...
Continuum: Cognitive Syndromes Associated With Movement Disorders - Part 1
25 Jul 2022
Contributed by Lukas
In part 1 of a 2-part series, Jennifer G. Goldman, MD, MS, FAAN, discusses her article, "Cognitive Syndromes Associated With Movement Disorders" from ...
Continuum: Dementia
22 Jul 2022
Contributed by Lukas
Dr. John C. Morris, MD, FAAN shares what he learned as the guest editor of the June 2022 Continuum issue on Dementia. This podcast is sponsored by ar...
Positive Airway Pressure and Cognitive Disorders in OSA
21 Jul 2022
Contributed by Lukas
Dr. Monica Shieu discusses the Neurology article, "Positive Airway Pressure and Cognitive Disorders in Adults With Obstructive Sleep Apnea: A Syst...
Social Isolation and Dementia
20 Jul 2022
Contributed by Lukas
Prof. Barbara Sahakian discusses the associations of social isolation and loneliness with later dementia. Show references: https://n.neurology.org/c...
Genome-Wide Migraine Study - Part 2
19 Jul 2022
Contributed by Lukas
Dr. Mikko Kallela discusses the paper, "Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles" in ...
Genome-Wide Migraine Study - Part 1
18 Jul 2022
Contributed by Lukas
Dr. Mikko Kallela discusses the paper, "Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles" in...
Runner's Dystonia
15 Jul 2022
Contributed by Lukas
Dr. Trevor Hawkins discusses repetitive exercise dystonia.
Psychiatric Co-Morbidities of Idiopathic Intracranial Hypertension
14 Jul 2022
Contributed by Lukas
Prof. Rigmor Jensen discusses psychiatric co-morbidities in patients with idiopathic intracranial hypertension. Read the full article in Neurology. ...
Continuum: Alzheimer Disease - Part 3
13 Jul 2022
Contributed by Lukas
In part 3 of a 3-part series, Eric M. McDade, DO, discusses his article, "Alzheimer Disease" from the June Continuum Dementia issue. This article and...
Continuum: Alzheimer Disease - Part 2
12 Jul 2022
Contributed by Lukas
In part 2 of a 3-part series, Eric M. McDade, DO, discusses his article, "Alzheimer Disease" from the June Continuum Dementia issue. This article an...
Continuum: Alzheimer Disease - Part 1
11 Jul 2022
Contributed by Lukas
In part 1 of a 3-part series, Eric M. McDade, DO, discusses his article, "Alzheimer Disease" from the June Continuum Dementia issue. This article an...
Careers in Neurology: Health Services Research
08 Jul 2022
Contributed by Lukas
Dr. Katrina Ignacio discusses the emerging subspecialty of health services research (HSR).
Maternal Serotonergic Antidepressant Use in Pregnancy and Risk of Seizures in Children
07 Jul 2022
Contributed by Lukas
Kelsey Kathleen Wiggs discusses her article in Neurology, "Maternal Serotonergic Antidepressant Use in Pregnancy and Risk of Seizures in Children". S...
Ted Burns: A Podcast In Memoriam
06 Jul 2022
Contributed by Lukas
A tribute to Dr. Ted Burns, the founder, and creator of the Neurology Podcast and the Neurology Minute, who recently passed away after a 9-year battle...
Optic Nerve MRI
05 Jul 2022
Contributed by Lukas
Dr. Justin Abbatemarco discusses the Neurology: Neuroimmunology & Neuroinflammation article "Optic Nerve Lesion Length at the Acute Phase of Optic Neu...
GABAa Encephalitis
04 Jul 2022
Contributed by Lukas
Dr. Justin Abbatemarco discusses the features of anti-γ-aminobutyric acid type A (anti-GABAA) receptor encephalitis.
Antisense Oligonucleotide Suppression of Mutant C9orf72
01 Jul 2022
Contributed by Lukas
Dr. Robert Brown discusses the Nature Medicine article, "Suppression of Mutant C9orf72 Expression by a Potent Mixed Backbone Antisense Oligonucleotide...
Cognitive Syndromes Associated with COVID
30 Jun 2022
Contributed by Lukas
Dr. Avi Nath discusses COVID brain fog and other cognitive syndromes. Show references: https://www.washingtonpost.com/health/2022/03/27/covid-brai...
The Value of Neuroimaging in Dementia Diagnosis - Part 3
29 Jun 2022
Contributed by Lukas
In part 3 of a 3-part series, Cyrus A. Raji, MD, Ph.D., discusses his article, "The Value of Neuroimaging in Dementia Diagnosis" from the June Continu...
The Value of Neuroimaging in Dementia Diagnosis - Part 2
28 Jun 2022
Contributed by Lukas
In part 2 of a 3 part series, Cyrus A. Raji, MD, Ph.D., discusses his article, "The Value of Neuroimaging in Dementia Diagnosis" from the June Continu...
The Value of Neuroimaging in Dementia Diagnosis - Part 1
27 Jun 2022
Contributed by Lukas
In part 1 of a 3 part series, Cyrus A. Raji, MD, Ph.D., discusses his article, "The Value of Neuroimaging in Dementia Diagnosis" from the June Continu...
Careers in Neurology: Clinical Development
24 Jun 2022
Contributed by Lukas
Dr. Katrina Ignacio discusses the emerging subspecialty of clinical development.
Corticosteroids in LGI1 Antibody Encephalitis
23 Jun 2022
Contributed by Lukas
Dr. Sarosh Irani discusses the use of corticosteroids as a first-line agent in the treatment of LGI1-antibody encephalitis.
NINDS Mission and Clinical Neurology with Walter Koroshetz
22 Jun 2022
Contributed by Lukas
Dr. Walter Koroshetz, Director of the National Institute of Neurological Disorders and Stroke, discusses the NINDS's mission and clinical neurology.
Neurosarcoidosis - Part 2
21 Jun 2022
Contributed by Lukas
Dr. Shuvro Roy discusses Neurosarcoidosis in part 2 of a 2 part series.
Neurosarcoidosis - Part 1
20 Jun 2022
Contributed by Lukas
Dr. Shuvro Roy discusses Neurosarcoidosis in part 1 of a 2 part series.
Maintenance Intravenous Immunoglobulin Prevents Relapse in Adult Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease
17 Jun 2022
Contributed by Lukas
Dr. Rae Bacharach discusses the Neurology Today article, "Maintenance Intravenous Immunoglobulin Prevents Relapse in Adult Myelin Oligodendrocyte Gl...
Medicare Limitation of Aduhelm
16 Jun 2022
Contributed by Lukas
Dr. Ron Petersen, Director of the Mayo Clinic Alzheimer's Disease Research Center, discusses Medicare's recent decision to officially limit Aduhelm (...
EEG Patterns and Neurofilament Light After Cardiac Arrest
15 Jun 2022
Contributed by Lukas
Dr. Linnéa Grindegård discusses the association between EEG patterns and serum neurofilament light as a marker of neuroaxonal injury after cardiac ...
Adult Opsoclonus-Myoclonus Syndrome
14 Jun 2022
Contributed by Lukas
Dr. Justin Abbatemarco discusses Adult Opsoclonus-Myoclonus Syndrome.
Pediatric Opsoclonus-Myoclonus Syndrome
13 Jun 2022
Contributed by Lukas
Dr. Justin Abbatemarco discusses Pediatric Opsoclonus-Myoclonus Syndrome.
Early Detection of Parkinson's Disease
10 Jun 2022
Contributed by Lukas
Dr. Halley Alexander discusses the Neurology Today article, "Potential Parkinson's Risks Found Years Before Diagnosis". Show references: https://jour...
Race-Ethnic Disparities in Stroke Thrombolysis
09 Jun 2022
Contributed by Lukas
Dr. Scott Mendelson discusses racial and ethnic disparities in the rates of declination of thrombolysis in patients with acute ischemic stroke. Sh...
A Review of L-arginine in MELAS
08 Jun 2022
Contributed by Lukas
Dr. Gráinne Gorman discusses the use of L-arginine in the treatment of mitochondrial encephalopathy, lactic acidosis, and strokelike episodes (MELAS...
Post-Concussion Headache
07 Jun 2022
Contributed by Lukas
Dr. Meeryo Choe discusses post-concussion headaches, from the May NeuroPanels webinar series. Show references: https://learning.aan.com/diweb/catalog/...
Development of New or Enlarging MRI Lesions Rare in MOGAD
06 Jun 2022
Contributed by Lukas
Dr. Stephanie Syc-Mazurek discusses her abstract, "Development of new or enlarging MRI lesions outside of attacks is rare in myelin oligodendrocyte gl...
Fentanyl Exposure
03 Jun 2022
Contributed by Lukas
Dr. Derek Stitt discusses facts and the misinformation surrounding fentanyl exposure.
Pure Sleep Epilepsy in Patients With First Seizure
02 Jun 2022
Contributed by Lukas
Dr. Elaine Pang discusses the identification and characterization of pure sleep epilepsy after first-ever seizures from sleep in adults. Show refe...
Quality of Life for Patients with Parkinson's Disease
01 Jun 2022
Contributed by Lukas
Dr. Meredith Bock discusses her paper about the association of motor, non-motor, and behavioral symptoms with health-related quality of life in peopl...
Continuum: Epilepsy
31 May 2022
Contributed by Lukas
Dr. Nathalie Jetté shares what she learned as the guest editor of the April 2022 Continuum issue on Epilepsy.
Acute Symptomatic Seizures Secondary to MOGAD
31 May 2022
Contributed by Lukas
Dr. Mayra Montalvo discusses her abstract, "Acute Symptomatic Seizures Secondary to Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder" ...
Neurodegeneration in Pro Football Players - Part 2
27 May 2022
Contributed by Lukas
Dr. Ann McKee continues her discussion on her recent study, which found that NFL players are at a higher risk for amyotrophic lateral sclerosis (ALS)...
Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia In Children
26 May 2022
Contributed by Lukas
Dr. Ming Lim discusses the diagnosis and management of opsoclonus myoclonus ataxia syndrome (OMAS) in children. Show references: https://nn.neurolog...
Neurology on the Hill: Telehealth
25 May 2022
Contributed by Lukas
Dr. Nassim Zecavati discusses one of the 2022 Neurology on the Hill issues: Extend Telehealth Flexibilities. Follow the event on social media using...
Neurology on the Hill: Barriers to Care
24 May 2022
Contributed by Lukas
Dr. Tyler Allison discusses one of the 2022 Neurology on the Hill issues: Address Overly Burdensome Barriers to Care. Follow the event on social med...
Neurology on the Hill: Support the Neurology Workforce
23 May 2022
Contributed by Lukas
Dr. Umer Najib discusses one of the 2022 Neurology on the Hill issues: Neurology Workforce. Follow the event on social media using #NOH22. Show ref...
The High Cost of Multiple Sclerosis
20 May 2022
Contributed by Lukas
Dr. Rae Bacharach discusses the Neurology Today article, "Multiple Sclerosis Costs More Than $85 Billion Annually, New Study Finds the Policy Change...
Neurodegeneration in Pro Football Players
19 May 2022
Contributed by Lukas
Dr. Ann McKee discusses her recent study, which found that NFL players are at a higher risk for amyotrophic lateral sclerosis (ALS). Show references...
Peripheral Neuropathy Evaluations of Patients with Prolonged Long COVID
18 May 2022
Contributed by Lukas
Dr. Anne Oaklander discusses the association of long COVID with incident polyneuropathy affecting the small-fiber axons. Show references:https://nn....
Approach to the Medical Treatment of Epilepsy - Part 2
17 May 2022
Contributed by Lukas
In part 2 of a 2 part series, Francesco Brigo, MD, discusses his article, "Approach to the Medical Treatment of Epilepsy" from the April Continuum Epi...
Approach to the Medical Treatment of Epilepsy - Part 1
16 May 2022
Contributed by Lukas
In part 1 of a 2 part series, Francesco Brigo, MD, discusses his article, "Approach to the Medical Treatment of Epilepsy" from the April Continuum Epi...
Bilateral Gene Therapy for Leber Hereditary Optic Neuropathy
13 May 2022
Contributed by Lukas
Dr. Nancy Newman discusses her abstract, "The Phase III REFLECT Trial: Efficacy and Safety of Bilateral Gene Therapy for Leber Hereditary Optic Neurop...
Neuromodulation Restores Function in Spinal Cord Injury
11 May 2022
Contributed by Lukas
Dr. Andreas Rowald discusses the efficacy of activity-dependent spinal cord neuromodulation, which was shown to rapidly restore trunk and leg motor fu...
Cardiac Arrhythmia in Patients with Drug-Resistant Epilepsy
11 May 2022
Contributed by Lukas
Dr. Shobi Sivathamboo discusses the incidence of serious cardiac arrhythmias detected by subcutaneous cardiac monitors in patients with chronic drug-r...
Genetics and Neuroinflammation, Considerations for the Clinician - Part 4
10 May 2022
Contributed by Lukas
Dr. Justin Abbatemarco discusses Alexander disease.
Genetics and Neuroinflammation, Considerations for the Clinician - Part 3
09 May 2022
Contributed by Lukas
Dr. Justin Abbatemarco discusses Adrenoleukodystrophy (ALD).
PNES Semiology
06 May 2022
Contributed by Lukas
Dr. Michael Kentris discusses psychogenic non-epileptic spells [PNES].
Prognosis and Treatment of Spinal Cord Sarcoidosis
05 May 2022
Contributed by Lukas
Dr. Antoine Gavoille discusses the prognostic factors and efficacy of immunosuppressive treatments for spinal cord sarcoidosis. Show references: htt...
Cost Burden of MS in the U.S.
04 May 2022
Contributed by Lukas
Dr. Bruce Bebo discusses the economic burden of multiple sclerosis in the U.S. Show references: https://n.neurology.org/content/early/2022/04/13/WN...
Genetics and Neuroinflammation, Considerations for the Clinician - Part 2
03 May 2022
Contributed by Lukas
Dr. Shuvro Roy discusses TNF-alpha Antagonism.
Genetics and Neuroinflammation, Considerations for the Clinician - Part 1
02 May 2022
Contributed by Lukas
Dr. Shuvro Roy discusses CTLA4 Haploinsufficiency.
Combined Prophylactic Treatment of Chronic Migraine
29 Apr 2022
Contributed by Lukas
Audrey Blazek, a 4th-year medical student at Rush Medical College, discusses her abstract, "Combined Prophylactic Treatment of Chronic Migraine with O...
Sudden Death and Cardiac Arrhythmia with Lamotrigine
28 Apr 2022
Contributed by Lukas
Dr. Mark Keezer discusses the risk of sudden death and cardiac arrhythmia in patients utilizing lamotrigine to treat epilepsy. Show references:htt...
Cognitive Decline in Patients with Parkinson's disease
27 Apr 2022
Contributed by Lukas
Dr. Michael Fox discusses whether connectivity between sites of deep brain stimulation (DBS) and other brain regions is associated with DBS-induced c...
Evaluation of First Seizure and Newly Diagnosed Epilepsy - Part 2
26 Apr 2022
Contributed by Lukas
In part 2 of a 2 part series, Elaine Wirrell, MD, FRCP(C), FAAN, discusses her article, "Evaluation of First Seizure and Newly Diagnosed Epilepsy" fro...
Evaluation of First Seizure and Newly Diagnosed Epilepsy - Part 1
25 Apr 2022
Contributed by Lukas
In part 1 of a 2 part series, Elaine Wirrell, MD, FRCP(C), FAAN, discusses her article, "Evaluation of First Seizure and Newly Diagnosed Epilepsy" fro...
Management of Stroke due to ICAD
22 Apr 2022
Contributed by Lukas
Dr. Zafer Keser reviews the article, "Stroke Prevention in Symptomatic Large Artery Intracranial Atherosclerosis Practice Advisory" published in the M...
Amyloid Treatments for Alzheimer Disease
21 Apr 2022
Contributed by Lukas
Dr. Gregg Day discusses amyloid-targeting treatments for Alzheimer's disease as well as how to navigate conversations about aducanumab with patients.
Priorities from the 2022 ADRD Summit with Walter Koroshetz
20 Apr 2022
Contributed by Lukas
Dr. Walter Koroshetz, Director of NINDS, discusses the priorities and outcomes at the 2022 Alzheimer's Disease-Related Dementias (ADRD) Summit.
Pre-pregnancy Migraine and Risk of Adverse Pregnancy Outcomes
19 Apr 2022
Contributed by Lukas
Dr. Purdue-Smithe discusses her abstract, "Pre-pregnancy migraine and risk of adverse pregnancy outcomes". Show references: https://index.mirasmart.co...
Teleneurology Reduces Wait Time
18 Apr 2022
Contributed by Lukas
Dr. Matthew Hart discusses his abstract, "Hospital Teleneurology Role Leads to Significant Wait Time Reduction for Follow Up Appointments and Increase...
Spinal Cord Stimulation for Painful Diabetic Neuropathy
15 Apr 2022
Contributed by Lukas
Dr. Erika Peterson discusses her abstract, "Durability of 10-kHz Spinal Cord Stimulation for Painful Diabetic Neuropathy: 18-Month Multicenter Randomi...
GBM and Lomustine
14 Apr 2022
Contributed by Lukas
Dr. Howard Colman discusses the availability of lomustine for the treatment of glioblastoma multiforme (GBM) in light of the drug's recent withdrawal...
Neurologic Causes of Post-Partum Readmission
13 Apr 2022
Contributed by Lukas
Dr. Barbara Decker discusses maternal obstetric complications and non-elective postpartum readmissions in women with prior stroke, migraine, multiple...
Neuropsychiatric and Cognitive Comorbidities in Epilepsy - Part 2
12 Apr 2022
Contributed by Lukas
In part 2 of a 2 part series, Marco Mula, MD, PhD, FRCP, FEAN, discusses his article, "Neuropsychiatric and Cognitive Comorbidities in Epilepsy" from ...
Neuropsychiatric and Cognitive Comorbidities in Epilepsy - Part 1
11 Apr 2022
Contributed by Lukas
In part 1 of a 2 part series, Marco Mula, MD, Ph.D., FRCP, FEAN, discusses his article, "Neuropsychiatric and Cognitive Comorbidities in Epilepsy" fro...
Careers in Neurology: Neuroinformatics
08 Apr 2022
Contributed by Lukas
Dr. Katrina Ignacio discusses the emerging subspecialty of Neuroinformatics.
Genetic Testing of White Matter Disorders
07 Apr 2022
Contributed by Lukas
Dr. Aurora Pujol discusses diagnosing genetic white matter disorders by singleton whole-exome and whole-genome sequencing using interactome-driven pr...
Patient Centered Treatment of Migraine with Medication Overuse
06 Apr 2022
Contributed by Lukas
Dr. Todd Schwedt discusses the treatment of chronic migraine with medication overuse through the patient-centered Medication Overuse Treatment Strate...
Magnetic Resonance Imaging Criteria at Onset to Differentiate Pediatric MS from Acute Disseminated Encephalomyelitis
05 Apr 2022
Contributed by Lukas
Dr. Magnus Boesen discusses his abstract, "Magnetic Resonance Imaging Criteria at Onset to Differentiate Pediatric MS from Acute Disseminated Encephal...