TOP Harvard Scientist: These 5 Habits Are Aging You Faster | David Sinclair | FO562 Raj Shamani
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What are the five simple habits that can add 14 extra healthy years of life?
There was a study from Harvard that showed that the men who lived the longest, they actually had 14 years of extra healthy life if they just did five things. Don't overdrink, don't smoke, don't be overweight, don't stress, and eat healthy. If you just do the basics, that's already 14 extra healthy years. Wow. I'm a scientist, work at a Harvard Medical School, have been there for 25 years, and my goal in life is to improve the life of everybody on the planet, potentially treat or cure all diseases. Here's a good point that I want to make for everybody. There are other things aging as well, besides DNA damage. X-rays break your DNA, by the way, but I can guarantee it's aging you. Every time we go to a rock concert and we're blasting our ears, we go home with older ears than when we went to the concert.
Tell me the ideal protocol for a young person. Try to eat less than three meals a day. See if you can join a gym so you can lift weights. If your gym has a sauna, great. And move, move, move, move. So walk upstairs, don't take the elevator. Give me specifics. What kind of other protocols will make me better? If you're not a young child in your twenties, three main meals a day is too much. Reduce your number of meals down to two and you'll be good. That's been shown in many clinical trials to have vast health benefits.
I read that you need to eat small, six small meals in order to
grow and get better. When you do the research, it's marketing. Food companies, breakfast is not the most important meal of the day. That's a cereal company marketing. No way. It is. You're telling me about fasting. What most people do is they say, I'm going to stop eating for a day and see what happens. Then they say, this is too hard. I'm hungry.
How does DNA damage and the epigenome drive the aging process?
That's the wrong way to do it. The way you would do it is don't stop eating immediately. Just have a smaller meal each day or eat something that's filling like a lot of vegetables, perhaps some hot water. It's not just healthy to drink and cleans out your blood, but also it fills you up. You don't feel hungry. Once you get past three days, what happens is remarkable. I went from feeling a little bit hungry, a little bit tired to my brain turned on. My body was making what are called ketones and the brain loves them. They fuel the brain. I was super awake. I was also more energetic. Wow.
How? Okay. Explain from the basics, let's say, why do we age? And how every body cell or every body organ is aging differently. I have a little structure here that I brought
to show you this, to explain it. So this is a piece of DNA, okay? And actually I have another model to show you guys this.
I have a small favor to ask you. I need you to subscribe to our channel. The more subscribers we have, the better and bigger guests we can bring and provide you more value through these conversations. And the full audio experience of this show is also available on Spotify where you can follow us and listen to the new episodes as well. Now let's get into the episode. If someone's watching you for the first time, and they have no clue who you are and what you do. That's like most people
watching
this. No, no, of course. So many people know. My audience would definitely know you, like a lot of them. And we are honored to have you here.
Oh, thanks for having me on, Raj.
Thank you. But tell us, if someone's watching you for the first time, what you do and why they should listen to you for the next hour.
Goodness, well, the first part's easy. What I do is I'm a scientist, work at a Harvard Medical School, have been there for 25 years. And my goal in life is to improve the life of everybody on the planet in a big way, not just a little bit, not just one disease. But my goal is to potentially treat or cure all diseases, especially those that come with old age. So I work on aging and we are one of the leading labs to be able to reverse that process. And we've just started human clinical trials to reverse aging. And so I guess that sounds pretty interesting. If I just heard that, I might listen. But yeah, basically what I want to do today is explain why do we age?
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Chapters
7 chapters
1
What are the five simple habits that can add 14 extra healthy years of life?
0:00–1:29
2
How does DNA damage and the epigenome drive the aging process?
1:29–41:56
3
What is the information theory of aging and how does it explain epigenetic changes?
41:56–1:11:25
4
How does tissue‑specific aging affect disease and can it be reversed?
1:11:25–1:25:54
5
What is entropy in biology and can the loss of cellular information be restored?
1:25:54–1:47:49
6
Why are sugar, alcohol and poor diet the biggest hidden accelerators of aging?
1:47:49–2:10:12
7
What single habit can a busy person change today to add the most healthy years?
2:10:12–2:25:12
Speakers
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