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Something You Should Know

Why You Hate Uncertainty & The New Science of Living Longer

11 May 2026

Transcription

Transcript generated automatically by AI and may contain errors.

Chapter 1: What is the main topic discussed in this episode?

2.309 - 16.389 Mike Carruthers

Today on Something You Should Know. Have you ever had the solution to a problem just pop in your head? I'll explain why that happens. And uncertainty. Humans have never handled uncertainty very well.

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17.19 - 32.232 Simone Stolzhoff

You pair that with a more modern phenomenon, the decrease in our tolerance of uncertainty. With the rise of the internet, we have this increasing expectation that answers should be readily available and an increasing discomfort with not knowing.

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32.212 - 41.784 Mike Carruthers

Also, a simple phrase that will ease the tension in any conversation. And a leading endocrinologist on the good news about living longer.

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42.586 - 56.944 Dr. Florence Comite

There are more and more people we know for a fact that are living beyond 100. I do think 120 is possible in our lifetime. And the way to do that is not how to worry about longevity, but rather the quality of your life.

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57.805 - 60.649 Mike Carruthers

All this today on Something You Should Know.

61.895 - 75.973 Hillary Frank

Hey, it's Hillary Frank from The Longest Shortest Time, an award-winning podcast about parenthood and reproductive health. We talk about things like sex ed, birth control, pregnancy, bodily autonomy, and of course, kids of all ages.

Chapter 2: Why do we struggle with uncertainty in our lives?

76.434 - 91.733 Hillary Frank

But you don't have to be a parent to listen. If you like surprising, funny, poignant stories about human relationships and, you know, periods, The Longest Shortest Time is for you. Find us in any podcast app or at LongestShortestTime.com.

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93.603 - 105.79 Unknown

Something you should know. Fascinating intel. The world's top experts. And practical advice you can use in your life. Today, Something You Should Know with Mike Carruthers.

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107.086 - 129.043 Mike Carruthers

Have you ever had an answer to a problem or a solution to something you've been thinking about? It just pops in your head out of nowhere. No thinking, no effort, just there it is. It happens to almost everyone, and it's why it's a great topic to begin this episode with. I'm Mike Carruthers. This is Something You Should Know.

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129.023 - 143.104 Mike Carruthers

So when an answer just pops in your head, research shows that those aha moments often come after your brain has been quietly working on the problem in the background, connecting dots you weren't even aware of.

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Chapter 3: How can embracing uncertainty improve our resilience?

143.966 - 167.711 Mike Carruthers

And here's the surprising part. When people solve certain problems with this sudden insight, they're more likely to be right than when they grind through it step by step. Why? Because analytical thinking can get stuck in the obvious. Insight just skips over that. It jumps to patterns and connections you didn't see consciously. But you can't force it.

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167.891 - 198.281 Mike Carruthers

In fact, the harder you push, the less likely it is to happen. So when you're stuck, the best move might not be to think harder. It might be to step away and just let your brain catch up. And that is something you should know. Nobody likes uncertainty, not knowing what's going to happen about your job, your health, your relationships. It can feel very uncomfortable, even stressful.

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198.842 - 223.026 Mike Carruthers

And these days, it seems like we're surrounded by more uncertainty than ever. So what do we do? We try to eliminate it. We check our phone. We research. We scroll. We refresh. Looking for answers. Looking for certainty. But what if that instinct is actually making things worse? Because life isn't something you can fully predict or control.

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223.607 - 250.238 Mike Carruthers

And the more you try to force certainty, the more anxious, stuck, and frustrated you can become. In fact, there's growing evidence that people who are better at tolerating uncertainty tend to be more resilient, more creative, and better at navigating change. So how do you get more comfortable with not knowing? My guest says it's a skill, and one that's becoming more valuable than ever.

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251.18 - 267.563 Mike Carruthers

Simone Stolzhoff is a journalist and author whose work has appeared in the New York Times, the Atlantic, the Wall Street Journal, and more. His book is How to Not Know the Value of Uncertainty in a World that Demands Answers.

Chapter 4: What role do genetics play in our health and longevity?

268.364 - 283.737 Mike Carruthers

Simone, welcome. Thanks for having me, Mike. So uncertainty seems as if it has been a constant throughout time. So why is it so important right now? Why is it any more important now than ever before?

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284.155 - 302.232 Simone Stolzhoff

There are two things going on. The first is that uncertainty has actually ticked up in the last few years. So there's this great study that has tracked global uncertainty over time since the 80s. And it's found that the five highest measurements since the study began have all occurred in the last five years. So you think about

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302.212 - 327.375 Simone Stolzhoff

COVID, wars overseas, shifting tariff policies, the world is incredibly uncertain right now. But you pair that with a more modern phenomenon, which is the decrease in our tolerance of uncertainty. With the rise of the internet and mobile phones, we have this increasing expectation that answers should be readily available and an increasing discomfort with not knowing.

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327.355 - 346.678 Simone Stolzhoff

So I think phones do sort of two things. One is they rob us of the practice of sitting with what we don't know. And two, they bring all of the uncertainties around us into our pockets. So the world is more uncertain than ever. Our tolerance for uncertainty is in decline. And that's what leaves so many people feeling anxious and unmoored.

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347.059 - 351.304 Mike Carruthers

And that is the symptom then, anxious and worried.

351.959 - 369.495 Simone Stolzhoff

Yeah, I think we can all feel that on a personal level. Even on a more trivial example, whereas 10 years ago, I might have been okay not knowing the name of a given actor. Now I feel an almost involuntary need to reach into my pocket. We're just not as comfortable with sitting with what we don't know as we used to be.

369.847 - 398.973 Mike Carruthers

Yeah, well, that's actually, although a seemingly insignificant example, it's an interesting example because I justify that. Like, if I want to know how old is Harrison Ford, I have no idea. It's not that I, it doesn't feel like it's uncertainty because I don't know, but I don't really need to know, but because I can know. I'll look.

399.053 - 409.557 Mike Carruthers

It's not because I must know or that I feel anxious for not knowing. But since I can know, I'll look and say, oh, okay, well, that's his age and life goes on.

410.077 - 429.739 Simone Stolzhoff

Yeah, I mean, there's two problems that arise as an extension from this phenomenon. The first is that sometimes we expect to have definitive answers about things that aren't as knowable as Harrison Ford's age. So, for example, I do a lot of work with people trying to figure out what they want to do for their jobs.

Chapter 5: What are the five key biomarkers of health?

662.242 - 687.146 Simone Stolzhoff

I think when we are certain, it closes our minds. You think about it from the perspective of polarization and politics, or from the perspective of career, professional uncertainty. If we think we know exactly how the world is going to look in five years or exactly who someone is based on who they voted for in the last election, it closes our minds.

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687.286 - 707.476 Simone Stolzhoff

Whereas if we are uncertain, if we're able to be patient enough to wait, it allows us to see truth as it emerges. There's this great parable that I love that is illustrative of this phenomenon, which is called the Chinese farmer parable. And how it goes is there's a farmer whose horse runs away from his small village.

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708.018 - 731.61 Simone Stolzhoff

The next day, his neighbors come to his door and they say, we're so sorry to hear about your horse. And the farmer says, you know, maybe yes, maybe no. The next day, the horse comes back, and there are seven other wild horses that have followed it in tow. And the neighbors come to the door, and they say, you are so lucky. What great fortune. And the farmer says, maybe yes, maybe no.

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732.531 - 752.056 Simone Stolzhoff

The following day, the farmer's son is riding one of the wild horses and falls off and breaks his leg. And again, the neighbors return, and they say, what a tragedy. We're so sorry to hear about your son. And the farmer says, maybe yes, maybe no. And the day after that, generals from the military come to the small village to draft people into the war.

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752.597 - 759.368 Simone Stolzhoff

And because the son has broken his leg, he's able to skip the draft. Again, the neighbors say, you're so lucky.

Chapter 6: How can lifestyle choices impact genetic expression?

759.428 - 780.468 Simone Stolzhoff

And the farmer says, maybe yes, maybe no. I think that is the value of uncertainty and how it intersects with patience. When we are willing to be patient enough to see what actually transpires, as opposed to making assumptions about what the future will hold, we can see the world more accurately and not rush to judgment about what is to come.

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781.19 - 808.718 Mike Carruthers

But there are different levels of uncertainty, and I want to ask you about that in just a moment. I'm speaking with Simone Stolzhoff about uncertainty. He's author of a book called How to Not Know the Value of Uncertainty in a World that Demands Answers. So, Simone, it feels like there are two different kinds of uncertainty. There is uncertainty that is completely beyond your control,

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808.698 - 840.039 Mike Carruthers

And uncertainty, because I could get in my car and drive, and there's a possibility. I'm not sure. I'm uncertain if I'll get into an accident. But there are things I can do, like put on my seatbelt, that at least I'm doing something to protect myself. so that the uncertainty of imminent death anyway is reduced because I'm taking action. I'm doing something proactive to mitigate the uncertainty.

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841.16 - 856.238 Simone Stolzhoff

Yeah, I think you hit the nail on the head. You know, I think the first thing that I often tell people is when you're feeling the anxiety of uncertainty, the first thing to do is separate what you can and can't control. So many of us worry about things that are fundamentally out of our control.

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856.218 - 877.233 Simone Stolzhoff

And then when you think about the realm of what you can control, if you can take steps to get your desired outcome, do that. So put on your seatbelt. If you're worried about where you're going to go to college, try to put in the best application as possible. And if you go down the decision tree one layer deeper, plan for different potential contingencies.

877.754 - 897.868 Simone Stolzhoff

So rather than just have one fixed idea of how you think the future will go, try to think about how you might be able to plan for different potential futures. And the last thing I say is to try and find your anchors. When we are certain about some elements of our life, it makes it easier to hold uncertainty in others.

897.848 - 919.291 Simone Stolzhoff

So in your personal life, maybe that's a commitment to living in a particular place or a commitment to a particular person or a commitment to a set of values. But finding those anchors, finding those boulders that will remain steady amidst all of the changing winds makes it easier to handle some of those inevitable uncertainties that will come your way.

920.673 - 947.574 Mike Carruthers

It's interesting that it seems that a lot of uncertainty that we have is... unwarranted in the sense that most of the things that I look back on that I was stressed about and anxious about, uncertain about, things worked out. Things have a tendency to work out. We have what it takes to get through difficult times and come out the other end.

947.654 - 956.745 Mike Carruthers

It may not be exactly what we wanted, but it was never as bad as we felt when we were uncertain about it.

Chapter 7: What proactive steps can we take to reduce health risks?

1006.687 - 1029.173 Simone Stolzhoff

And so I think that's a great case for reserving judgment about how those future events might go. If you're able to heed some of the wisdom of the farmer and maintain a level of equanimity about how a given event might affect your life long term, you'll be able to maintain a little bit more of the peace of your mind and adapt more gracefully to whatever comes your way.

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1029.558 - 1051.553 Mike Carruthers

There is, it seems, like a mismatch between when you're uncertain about something, even something horrific. You know, if you're a parent of a child who's very sick, And you start to imagine, you know, if he dies or she dies, what would happen? And it's always catastrophe. And it is a catastrophe. It's like the worst thing in the world.

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1052.033 - 1075.304 Mike Carruthers

But people manage somehow, for the most part, to redo their lives or reorganize things or somehow in their mind... get on with their lives, even though it happened. But when they were predicting what would happen, it was far worse. Even in something horrific like that, people do manage to get on with their lives.

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1076.405 - 1103.1 Simone Stolzhoff

I profile a friend of mine named Emily Onhalt, and she is a therapist. She works with leaders navigating uncertainty and change in their work. But before she became a professional mental health therapist, practitioner. In her early 20s, her mom was diagnosed with a potentially terminal illness. And so Emily spent weeks by her mom's bedside at the hospital and she was really struggling to cope.

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1103.28 - 1122.212 Simone Stolzhoff

She was riding this roller coaster of anticipatory grief and fear. And one day, one of their family friends, this guy named Bill, who is an oncology doctor and has lots of experience dealing with people at the end of their lives, came to visit Emily. And he said, Emily, how are you doing? And Emily said, honestly, not very well.

1122.452 - 1148.481 Simone Stolzhoff

I don't know how I'll be able to handle it if my mom were to pass away. And Bill said, Emily, the version of you that will deal with that tragic event if or when it ever occurs will be born into existence in that moment. And that version of you will have more context, more information, and be better equipped to handle it than you are today.

1149.182 - 1175.023 Simone Stolzhoff

You have to trust in your future self to be able to handle your future problems. And I love that phrase, trust in your future self to handle your future problems for that exact reason that you just mentioned, Mike, which is that our brains have this natural tendency to spiral, to catastrophize, to think about all of the worst case scenarios. We often rush out to meet our suffering.

1175.003 - 1195.276 Simone Stolzhoff

And Emily is so glad that she didn't prematurely grieve before she had to because her mom ended up recovering and was okay in the hospital. But even if that weren't the case, I think that wisdom of our ability to adapt to our new situations is one of the most important human skills that we all have.

1195.917 - 1213.622 Simone Stolzhoff

And if we're able to heed Bill's advice to trust in our future self to be able to cultivate a sense of faith and hope, even in dark times, that is the skill that will help us handle any sort of sling or arrow the future brings us.

Chapter 8: How can a simple phrase transform difficult conversations?

1523.959 - 1545.749 Dr. Florence Comite

That's why even identical twins are different. So my twin and I like different things. We have different taste buds. I can live on sushi. She doesn't like fish. She's an amazing gardener. I murder plants, not people, but plants. And all along, there are other differences in the way our bodies express health and disease that we take care of in different ways.

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1545.769 - 1569.221 Dr. Florence Comite

There are certain medications she can take that I can't. And all of us are made in that fashion. So the real strength in understanding the path we're on is to look, if we can, to our parents and grandparents, aunts and uncles, because they have expressed diseases that are written into their DNA. But by living and making certain choices in life, you can stop that expression of disease.

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1569.421 - 1578.353 Dr. Florence Comite

You can actually turn a switch and change the way your body operates so that you don't have to get it's not inevitable. You don't have to get chronic disease as you age.

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1579.025 - 1592.494 Mike Carruthers

So when you go to the doctor, when I go to the doctor, you know, one of the first things they'll ask you is, you know, is there a history of this disease in your family? And they ask that question because why?

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1593.335 - 1603.53 Dr. Florence Comite

They ask that question because in the old days, it was an important piece of what we did. And asking about the family is important if you can implement what it tells you.

1603.59 - 1625.909 Dr. Florence Comite

So if you hear that someone's mother just got diagnosed with diabetes or a grandfather fell and broke his hip, you should be looking for those signs and symptoms deep within the patient's body, the person that's facing you, because it's already brewing under the surface. And that's why family history is important. but far too often it doesn't really get addressed in depth.

1626.832 - 1631.948 Mike Carruthers

What are these five biomarkers of health? What does that mean and what are they?

1632.485 - 1656.851 Dr. Florence Comite

over the years, what I designed, you know, over 20 years ago, before I came to New York, was looking at people through the lens of N of one, meaning each of us is unique. And again, that speaks to my innate knowledge of epigenetics that my twin and I have the exact same genes, but we express them differently. And as a result, I studied people in depth, I would get 100 to 150 lab tests.

1656.891 - 1681.662 Dr. Florence Comite

Today, we call them biomarkers. And I was able to tell if people were on a track to get a heart attack, to get dementia, to get osteoporosis or cancer. And so what I learned from that test, which I think of as real world research, is that there are five key biomarkers that everyone should request in their visit with a doctor or even try to do it online through a telemedicine company.

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