The rise of GLP-1s.
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What are the opening remarks and quick‑hit news items that set up the episode?
From executive producer Isaac Saul, this is Tangle.
Good morning, good afternoon, and good evening, and welcome to The Tangle Podcast, a place where you get views from across the political spectrum, some independent thinking, and a little bit of our take. This is editor Audrey Moorhead, and I am fresh off a family trip to Gatlinburg, Tennessee, nestled in the heart of the Smoky Mountains, where life is as peaceful as a baby's sigh. Gatlinburg is best known for its, shall we say, tackiness, but there is a quaint charm to the little town, and I'm really grateful that I could make my family's annual trip for the first time in five years. A lot has changed in the world in those five years, and today I'll be telling you about one such change, the rise of GLP-1 weight loss drugs.
Then, Senior Editor Will Kabak will give you a recap of the stories we didn't cover this week and some good news about the falling U.S. poverty rate. But first, I wanted to let you know about our latest Suspension of the Rules episode. It is a big Apple episode for Apple season. On the most recent Suspension of the Rules, Isaac, Ari, and Camille talk about the ongoing UN assembly in New York. Then they discuss the New York Times Magazine article about public schooling and race. And then someone has a complaint about leaves, and I think you can guess who it is. If you can't, it's Camille. Check out the conversation by heading over to Suspension of the Rules after you listen through today's podcast. In the meantime, I'll pass things off to Will, and I will be back for my take.
Thanks, Audrey. Okay, here are today's quick hits. Number one, a federal judge ordered the Trump administration to restore White House press credentials to CNN, MSNOW, and Politico reporters, finding that the administration's ban is likely unconstitutional. Number two, Iranian President Mazood Pazeshkian addressed the United Nations General Assembly, criticizing the U.S. and Israel for attacking his country and saying that it will fight the war, quote, until our last breath. Number three, Chinese President Xi Jinping arrived in Washington, D.C. for a state visit hosted by President Donald Trump. Shortly after Xi's arrival, the U.S. and China announced an extension of their trade truce until January 2027.
Number four, the 10-year treasury yield, the annual interest rate paid by the federal government to investors who own 10-year debt notes, rose to 5.14% on Wednesday, the highest rate since July 2007. And number five, acting Navy Secretary Hung Kao informed lawmakers that eight sailors assigned to the USS Abraham Lincoln Aircraft Carrier Strike Group attempted suicide during the ship's recent deployment to the Middle East.
the GLP-1 boom. Yeah, so their use has skyrocketed over the past few years. Close to 30 million people are now taking them. That's one in every eight adults. But achieving your desired results goes well beyond getting the prescription. It also goes beyond that number on the scale.
In recent years, use of new weight loss medications has risen in the United States. A 2026 Gallup poll found that a record 11% of U.S. adults are taking GLP-1 medications for weight loss, up from 3% in 2024.
How have GLP‑1 weight‑loss drugs surged in usage and what do the recent polls show?
Furthermore, high-profile figures like Illinois Governor J.B. Pritzker and decorated tennis player Serena Williams have extolled their experiences taking the drug. The rising prevalence of GLP-1 use for weight management has sparked a debate over the potential impact on health and wellness in the United States. GLP-1s, or glucagon-like peptide 1 agonists, are a class of medication that primarily treats type 2 diabetes and obesity. GLP-1 agonists mimic the GLP-1 hormone, which is made in the small intestine, to trigger insulin release, slow down digestion, and increase the feeling of fullness after eating. The Food and Drug Administration first approved GLP-1s for medical use in 2005, but their popularity has increased significantly in recent years with the introduction of brand names like Ozempic and WeGoVie.
The rising adoption of GLP-1s has coincided with U.S.
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Chapters
7 chapters
1
What are the opening remarks and quick‑hit news items that set up the episode?
0:03–3:44
2
How have GLP‑1 weight‑loss drugs surged in usage and what do the recent polls show?
3:44–8:52
3
What is the mechanism of action and FDA history behind GLP‑1 medications?
8:52–13:34
4
How do right‑leaning commentators view the benefits and risks of GLP‑1s?
13:34–18:12
5
What concerns do left‑leaning voices raise about GLP‑1s and eating‑disorder risk?
18:12–21:42
6
How does the host’s personal experience illustrate the cultural impact of GLP‑1s?
21:42–27:54
7
What dissenting perspective does the executive editor offer about long‑term societal effects?
27:54–28:43
Speakers
2 identifiedMore from Tangle
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