In this episode of The Biotech Startups Podcast, Richard Yu, co-founder and CEO of Abalone Bio, reflects on building a company around a bold scientific vision — and the personal moments that shaped his leadership along the way. He unpacks the core insight behind Abalone Bio's yeast-based screening platform: that conventional antibody discovery optimizes for binding over function, like grabbing scissors by the blades. Richard also opens up about the devastating loss of co-founder Gustavo Pesce in a 2021 skiing accident, how the team and investors rallied with unwavering support, and how that crisis ultimately sharpened his sense of purpose and focus. From weathering hundreds of investor rejections to landing partnerships with Pfizer and Sichuan Pharma, Richard offers an honest look at running a biotech startup with a platform-driven, portfolio-management mindset.

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