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The Human Upgrade: Biohacking for Longevity & Performance

Science Education Health & Fitness

Episodes

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This Legal Sleep Powder Beats Melatonin Every Time : 1440

29 Mar 2026

Contributed by Lukas

Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBEI have spent 20 years and over $2 million testing my biology, and the biggest l...

I Injected Stem Cells Into My Penis (Here's What Happened) : 1439

27 Mar 2026

Contributed by Lukas

Your brain is hardware, and if the hardware is broken, no supplement stack, nootropic, or biohacking protocol in the world will get you to full capaci...

Arthur Brooks | Why Your Life Has No Meaning : 1438

26 Mar 2026

Contributed by Lukas

What if the real reason you feel stuck, anxious, or unfulfilled has nothing to do with your biohacking stack and everything to do with which half of y...

This Popular Fat Loss Shortcut Destroys Your Youth : 1437

24 Mar 2026

Contributed by Lukas

Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people...

Give Me 21 Minutes And I'll Give You Perfect Vision Naturally : 1436

22 Mar 2026

Contributed by Lukas

Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBEI transformed my vision from 20/80 to 20/15 by stopping the "management of decl...

SNL Roasts MAHA, Pistachios Slap, ChatGPT Doctor Stats, Colon Cancer Under 50, and more... : 1435

20 Mar 2026

Contributed by Lukas

This week's stories: *SNL Roasts the MAHA Movement Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that...

Here's Why You Still Feel Like Sh*t After Doing Everything Right... : 1434

19 Mar 2026

Contributed by Lukas

Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong...

Hair Regrowth, Pain Relief, and Altered States — The Science Light : 1433

17 Mar 2026

Contributed by Lukas

What if a glowing pyramid sitting in your living room could restructure your biology, compress decades of meditation into minutes, and shift your brai...

This Nobel Prize Discovery Reverses Aging In 72 Hours : 1432

15 Mar 2026

Contributed by Lukas

Is aging an inevitable decline, or just a "repair backlog" your body hasn't cleared yet?. In this episode, Dave breaks down the 2016 Nobel Prize-winni...

Your Telomeres Are a Lie, Bats Beat Aging, Sleep Meds Ruin Mornings, CO's Silent Kill, and more... : 1431

13 Mar 2026

Contributed by Lukas

This week’s stories: Smartphone App Catches What Sleep Trackers Miss A 2026 trial found that suvorexant, a popular prescription sleep drug...

Your Penis Is a Longevity Organ (Here's How to Hack It) : 1430

12 Mar 2026

Contributed by Lukas

Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it. -Watch t...

AI Expert Says: Humans Are Just Mystical Meat Robots : 1429

10 Mar 2026

Contributed by Lukas

What if understanding how AI thinks could reveal uncomfortable truths about how your own brain works, and give you powerful tools to make smarter deci...

How I Finally FIXED My Terrible Sleep After 18 Years : 1428

08 Mar 2026

Contributed by Lukas

Block toxic light with these glasses: https://truedark.com/discount/DAVETUBEThink 8 hours of sleep is enough? Think again. I used to think I had a sle...

WW3 Doomscrolling, 5 Minute Sleep Hack, Diet Wars, Dopamine Supplements : 1427

06 Mar 2026

Contributed by Lukas

This week’s stories: Healthy Diets That Offset "Bad Genes" A major UK Biobank study of over 100,000 people found that following ...

Your Brain Is 0.5% Plastic (Here’s How to Flush It) : 1426

05 Mar 2026

Contributed by Lukas

Microplastics are invading your brain, blood, hormones, and fat tissue, and most people have no idea how deep the damage goes. In this episode, Host D...

Why Are Hackers Microdosing “Sex Drugs” Now? : 1425

03 Mar 2026

Contributed by Lukas

Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like th...

A-List Celebrities' Anti-Aging Hack to Look 30 At 50 (Drug-free) : 1424

01 Mar 2026

Contributed by Lukas

What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young?S...

Mexican Cartel Biohacking, Google Anti-Aging Breakthrough, Measles Is Back, Age Reversal In 2026 : 1423

27 Feb 2026

Contributed by Lukas

This week’s stories: Sinclair’s This Is the Test: Are we about to see age reversal in humans? At the World Governments Summit ...

The Secret to Staying DANGEROUS After 50 : 1422

26 Feb 2026

Contributed by Lukas

Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist.&...

The Home Laser That Reverses Skin Age By 20 Years : 1421

24 Feb 2026

Contributed by Lukas

Your skin is not just a cosmetic surface. It’s a living organ that responds to signals, and the right light signal can flip your biology i...

I Tested The Most Dangerous Viral Brain Hack : 1420

22 Feb 2026

Contributed by Lukas

Most people try to fix brain fog and focus issues with caffeine or nootropics, but those approaches only mask the problem.This video explains that bra...

Plastic in Your Testicles, AI Sleep Scans, The 29% Weight Loss Drug : 1419

20 Feb 2026

Contributed by Lukas

This episode covers: • Microplastics Are Destroying Male Fertility and Metabolism New research is putting microplastics in ...

Change Your Morning, Change Your Life – Hal Elrod : 1418

19 Feb 2026

Contributed by Lukas

Meet a man who makes miracles happen. Today, we revist my conversation with Hal Elrod, author of the international bestseller The ...

The Secret to Looking Younger is in Mushrooms (And Chocolate?) : 1417

17 Feb 2026

Contributed by Lukas

Your gray hair, thinning lashes, brain fog, and that low energy feeling after 30 might all trace back to one thing: falling NAD and stressed mitochond...

Low Testosterone Starts In Your Eyes (Avoid This Before Bed) : 1416

15 Feb 2026

Contributed by Lukas

https://truedark.com/discount/DAVETUBEMost people believe testosterone declines simply because of age. That explanation is easy, familiar, and wrong. ...

Jet Lag Superdrug, 25% Dementia Drop, Coffee Brain Aging, Kratom Shakeup : 1415

13 Feb 2026

Contributed by Lukas

This episode covers: • Mic-628 Could Reset Your Body Clock and Cut Jet Lag in Half A new circadian drug candidate, Mic-628, has demon...

Turn Off Your WiFi Tonight and See What Happens to Your Sleep : 1414

12 Feb 2026

Contributed by Lukas

Your phone, your lighting, and your WiFi can mess with your sleep and energy more than your diet, and this episode shows you the simplest fi...

The Secret Peptides and Underground Compounds Doctors Won’t Talk About : 1413

10 Feb 2026

Contributed by Lukas

What if the line between “medicine” and “forbidden” has nothing to do with safety and everything to do with permission? This episode gives you...

Why Your Muscles Break Down After 40 (Do This To Reverse It) : 1412

08 Feb 2026

Contributed by Lukas

Your muscles play a far bigger role in aging than most people realize. As you get older, the energy factories inside your muscle cells begin to break ...

Biohackers in the Epstein Files, Generic GLP-1s, Continuous Ketone Monitors, and more... : 1411

06 Feb 2026

Contributed by Lukas

This episode covers: • Longevity Influence In The Epstein Files A new DOJ document release tied to the Epstein investigatio...

Why 18-Year-Olds Wake Up Fresh (And You Don't) : 1410

05 Feb 2026

Contributed by Lukas

18-year-olds wake up fresh because their repair system still works. This episode shows you how stem cell decline quietly drives fatigue, inflammation,...

STOP Intermittent Fasting If You Want to Stay Young : 1409

03 Feb 2026

Contributed by Lukas

STOP intermittent fasting if you think it automatically keeps you young. In this episode, you’ll learn why short-term fasting results can ...

Aging Starts In Your Legs (Here’s The Fix) : 1408

01 Feb 2026

Contributed by Lukas

Most people think aging starts with wrinkles, gray hair, or memory loss. It doesn’t.Aging starts when your legs begin to weaken, long before you not...

The Nobel Prize Molecule That Nearly Doubles Lifespan : 1407

30 Jan 2026

Contributed by Lukas

In the late 1990s, a strange carbon molecule quietly delivered the single longest lifespan extension ever recorded in mammals. The rats lived about 90...

Meet the Governor Who Wants Humans to Become Cyborgs : 1406

29 Jan 2026

Contributed by Lukas

Aging is not something Zoltan Istvan plans to accept quietly. He wants to treat death like a technical bug, rewrite the rules of biology, and turn Cal...

Your Butt is a Longevity Organ (Here’s how to train it!) | Gabrielle Lyon : 1405

27 Jan 2026

Contributed by Lukas

Your butt is not about aesthetics. It is a longevity organ that directly impacts metabolism, brain optimization, resilience, and how long yo...

The Natural Ozempic In Your Gut (Eat THIS To Switch It On) : 1404

25 Jan 2026

Contributed by Lukas

Your gut already has its own version of Ozempic, and it’s been doing this job long before injections existed.In this video, I explain how appetite i...

Biohacking News Weekly Update : 1403

23 Jan 2026

Contributed by Lukas

This episode covers: • Real Food Reset in U.S. Dietary Policy The new Dietary Guidelines for Americans 2025–2030 put real food back at t...

This Brain Trick Feels Like Cheating (Do THIS) : 1402

22 Jan 2026

Contributed by Lukas

Most brain decline, mood instability, and impulsive behavior start with a breakdown in how the brain’s immune cells produce and use energy. This epi...

Inside the Mind of the Mad Scientist Rewriting Aging : 1401

20 Jan 2026

Contributed by Lukas

Your body does not fail all at once. Aging starts when cells quietly shift into survival mode and never come back out. In this episode, you ...

I Lost 100 Pounds Of Fat By Drinking Fat (Just Do This) : 1400

18 Jan 2026

Contributed by Lukas

One freezing sip on a Tibetan mountain rewired his hunger, silenced cravings, and unlocked a kind of fat-burning “switch” no doctor ever mentioned...

The Superbrain Drug Politicians Use To Outsmart Everyone : 1399

16 Jan 2026

Contributed by Lukas

This drug has been misunderstood for decades, and that confusion is costing people focus, learning speed, and cognitive performance. In this...

Why 65% of People SUCK at Modern Relationships : 1398

15 Jan 2026

Contributed by Lukas

Most people are struggling in modern relationships, and it is not because they are broken. It is because the systems around them are. In this episode,...

The 12 Greatest Mood Boosters on Earth : 1397

13 Jan 2026

Contributed by Lukas

Mood, motivation, and emotional resilience are not personality traits. They are biological systems. In this episode, you’ll get the 12 gre...

I Cracked The Code To Staying Lean In My 50s (Here's How) : 1396

11 Jan 2026

Contributed by Lukas

Most people think fasting is just about skipping breakfast. But what if 72 hours without food could actually reverse aging?In this video, Dave Asprey ...

Reversing The American Food Pyramid | Calley Means : 1395

09 Jan 2026

Contributed by Lukas

Back in 2024 with Calley Means at South by Southwest, we sat down and talked about his mission to flip the old American food pyram...

The Willpower Drug: How to Supplement Discipline : 1394

08 Jan 2026

Contributed by Lukas

Creatine is a hot subject right now, but I’m guessing you might not know as much about it as you could. Well step into a new&nbs...

How Long Can Humans Really Live… (with Dan Buettner) : 1393

06 Jan 2026

Contributed by Lukas

You’re about to hear one of the most honest longevity conversations ever recorded. This co hosted episode brings together two longevi...

This Legal Boner Pill Is Hiding A Future Heart Attack : 1392

04 Jan 2026

Contributed by Lukas

Most men think ED is just a performance issue. It’s not. It’s one of the earliest warning signs of cardiovascular decline and it often appears yea...

Biohacking News Weekly Update : 1391

02 Jan 2026

Contributed by Lukas

This episode covers: • Colon Cancer in the Young and Why Risk May Start in Infancy New reporting highlights a troubling rise in early...

The Secret Federal Plan to Feed Us Legal Poison : 1390

01 Jan 2026

Contributed by Lukas

You’re about to learn how government approved food policies, regulatory loopholes, and corporate lobbying have quietly reshaped what’s&n...

These 7 Superfoods Are Secretly Wrecking Your Body : 1389

30 Dec 2025

Contributed by Lukas

This solo masterclass on oxalates explains why many people who eat clean still struggle with joint pain, kidney stones, fatigue, brain fog, and chroni...

I Lost 100 Pounds By Fasting Like THIS (The Missing Step) : 1387

28 Dec 2025

Contributed by Lukas

This video reveals the hidden mistake most people make when fasting that causes muscle loss instead of fat loss. You’ll learn how to flip the body’...

Biohacking News Weekly Update : 1388

26 Dec 2025

Contributed by Lukas

This episode covers: • Trump Drug Pricing Deals and Access to Longevity Medications New drug-pricing agreements announced under President ...

How to Get and Stay Sober in 2026 (The Biohacker’s Guide) | Luke Storey : 1386

25 Dec 2025

Contributed by Lukas

The holidays are when drinking quietly ramps up for a lot of people. More parties, more stress, more excuses, and habits that feel temporary but often...

What it takes to be “Young Forever!” | Mark Hyman : 1385

23 Dec 2025

Contributed by Lukas

Most conversations about longevity focus on tactics. This episode breaks down the biology underneath them. You’ll hear a systems level ana...

I Tried $50 Brain Boosting Powder : 1384

21 Dec 2025

Contributed by Lukas

Try LMNT and get a FREE gift: https://partners.drinklmnt.com/free-gift-with-purchase?rfsn=5182916.370beb&utm_medium=sponsor&utm_source=da...

Biohacking News Weekly Update : 1383

19 Dec 2025

Contributed by Lukas

This episode covers: • FDA Loosens Supplement Warning Labels The FDA is considering a rule change that would allow supplement co...

The Science of Erotic Altered States | Biohacking Sex : 1382

18 Dec 2025

Contributed by Lukas

This episode explores how intimacy, desire, and erotic states function as powerful tools for healing, nervous system regulation, and personal transfor...

Biohacking Fertility for Men and Women at Any Age : 1381

16 Dec 2025

Contributed by Lukas

This episode lays out the blueprint for having healthier children later in life by treating preconception as the most important window for h...

Your Brain Has A Sleep Switch (Do THIS To Turn It On) : 1380

14 Dec 2025

Contributed by Lukas

Try TrueDark Glasses: https://truedark.com/?coupon-code=DAVETUBE&sc-page=shopKill your zombie cells with: http://www.qualialife.com/davenadYour br...

The One Thing Everyone Thinks They Can’t Afford… Until They Try It : 1379

12 Dec 2025

Contributed by Lukas

If you want more time, better energy, and a calmer mind, this episode gives you a blueprint for achieving it. Host Dave Asprey talks with entrepreneur...

How To Sculpt a Perfect Jawline WITHOUT Surgery : 1378

11 Dec 2025

Contributed by Lukas

Your jaw influences far more than your face. This episode shows you how jaw strength shapes cognition, posture, airway health, sleep, metabolism, and ...

I Tried At-Home Ultrasound for My Brain : 1377

09 Dec 2025

Contributed by Lukas

Most people stay locked in a constant sympathetic state without realizing it, which drains focus, sleep quality, emotional balance, and long-term resi...

What If You Stop Eating For 72 Hours? : 1375

07 Dec 2025

Contributed by Lukas

Most people think fasting is just about skipping breakfast. But what if 72 hours without food could actually reverse aging?In this video, Dave Asprey ...

The Real Reason Your Face Is Aging So Fast : 1376

05 Dec 2025

Contributed by Lukas

Vitamin C, copper peptides, and glutathione behave very differently once you understand how skin absorbs nutrients at the cellular level. This episode...

Feel 70 Percent Better… With Grapes? | Biohacking Tools : 1374

04 Dec 2025

Contributed by Lukas

If you care about longevity, mitochondria, cardiovascular health, or feeling sharper every day, this episode gives you a clear look at the breakthroug...

The Machine That Flicks on Your Brain in 30 Seconds | Biohacker Tools : 1373

02 Dec 2025

Contributed by Lukas

This episode shows you how light, vibration, and frequency-based technology can shift your brain state in minutes, unlock deep neuroplasticity, releas...

How I Lost 100 Pounds By Drinking Butter Coffee : 1371

30 Nov 2025

Contributed by Lukas

In 1999, a Silicon Valley millionaire on the brink of collapse took one mysterious sip atop a frozen Tibetan mountain - and everything changed. That m...

Get a Full Body Workout in 10 Minutes by Doing NOTHING | Biohacks : 1372

28 Nov 2025

Contributed by Lukas

Most people think you need sweat, strain, or long workouts to upgrade circulation, metabolism, and energy. What if your body could unlock all of that ...

How to Stop Brain Fog After Anesthesia | Biohacker Tips : 1370

27 Nov 2025

Contributed by Lukas

Prepare to rethink surgery, healing, anesthesia, and recovery. This episode gives you a complete, high-performance playbook for surgical preparation a...

Why Breathwork Feels Like a Euphoric Drug | Biohacker Tips : 1369

25 Nov 2025

Contributed by Lukas

Breathwork is one of the most powerful tools in biohacking, yet most people only experience the surface level techniques. When you use it the right wa...

Dead Water Is Making You Sick! (Biohacking Bonus Episode) : 1368

24 Nov 2025

Contributed by Lukas

Here’s the hidden story behind why you can chug “pure” water all day and still feel foggy, drained, and oddly thirsty: most of what we drink is ...

10-Minute Biohacking News Update : 1367

21 Nov 2025

Contributed by Lukas

This episode covers: • Nano CBD Pain Relief Without Cognitive Side Effects A new nano-micelle formulation of CBD called CBD-IN delive...

The Methylene Blue Episode | Solo Biohacking Masterclass : 1366

20 Nov 2025

Contributed by Lukas

Methylene blue is one of the most misunderstood compounds in biohacking, yet it can upgrade your energy, mood, memory, and cellular resilience when yo...

The Tiny Implant Replacing Life-Changing Drugs | Biohacking Tools : 1365

18 Nov 2025

Contributed by Lukas

Bioelectronic medicine is changing how we treat inflammation, autoimmunity, and chronic disease, and this episode shows you exactly how nerve stimulat...

The Boring Secret Behind Celebrities Who Don’t Age : 1364

16 Nov 2025

Contributed by Lukas

What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young?S...

Biohacking News Weekly Update : 1363

14 Nov 2025

Contributed by Lukas

This episode covers: • Cocoa Extract Cuts Heart Deaths A massive COSMOS trial found that older adults taking high flavanol cocoa extract d...

How to Build Muscle WITHOUT Lifting! Biohacker Longevity : 1362

13 Nov 2025

Contributed by Lukas

Your workouts may be doing less than you think, and science now proves why. This episode reveals how to build muscle, improve metabolism, and extend l...

Why Motivation DOESN’T Work | Mental Biohacks : 1361

11 Nov 2025

Contributed by Lukas

True transformation doesn’t come from motivation. It comes from rewiring your mind, reshaping your beliefs, and mastering your percep...

New Japanese Walking Hack Burns More Fat Than 10,000 Steps : 1360

09 Nov 2025

Contributed by Lukas

Discover a little-known Japanese walking technique that outperforms 10,000 steps a day. It boosts fat burning, lowers stress, improves mitochondria, a...

Biohacking News Weekly Update : 1359

07 Nov 2025

Contributed by Lukas

Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. This episode breaks down the six biggest stories in biohacking an...

The Strange Science Behind Tylenol and Heartbreak | Daniel Amen : 1358

06 Nov 2025

Contributed by Lukas

Pain isn’t just in your body, it’s in your brain. In this groundbreaking episode, Host Dave Asprey sits down with Dr. Dan...

The New SCIENCE of Energy Healing | Biohacking Updated : 1357

04 Nov 2025

Contributed by Lukas

Your body does not just run on food or supplements. It runs on energy and information. This episode reveals how to harness that energy for faster reco...

Your Body Has an Anti-Aging Switch (Here’s How to Turn It On) : 1356

02 Nov 2025

Contributed by Lukas

What if getting older had less to do with your birthday and more to do with the health of your cells? Some people in their 50s feel stronger and sharp...

What Happens When You Live Inside a Quantum Field? (Anti-Aging Secrets) : 1355

31 Oct 2025

Contributed by Lukas

Discover how quantum energy, frequency medicine, and consciousness science are rewriting what’s possible for human performance and longevity. This e...

Master Stress in 10 Seconds with THIS Heartbeat Technique : 1354

30 Oct 2025

Contributed by Lukas

Heart rate variability isn’t just a fitness metric, it’s the master signal of human performance, emotional regulation, and longevity. This episode...

Biohacking Cannabis: The DNA Science of Plant Medicine : 1353

28 Oct 2025

Contributed by Lukas

Discover how decoding your DNA can unlock the full potential of plant medicine. This episode delivers a cannabis masterclass for biohackers, reve...

This Legal Focus Powder Beats Any Dopamine Detox : 1352

26 Oct 2025

Contributed by Lukas

Dopamine isn’t the enemy—low brain energy is. When your mitochondria can’t make enough ATP, your neurons misfire, leading to fatigue, brain fog,...

Biohacking News Weekly Update : 1351

24 Oct 2025

Contributed by Lukas

Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. This episode breaks down the five biggest stories in biohacking and he...

How Biohackers Use Nicotine WITHOUT Getting Addicted : 1350

23 Oct 2025

Contributed by Lukas

This is Part 2 of the Nicotine Masterclass. If you haven’t heard Part 1, start there for a full breakdown of nicotine’s mechanisms, myths, and the...

Why Women’s Joints Are Failing 10x Faster : 1349

21 Oct 2025

Contributed by Lukas

Modern joint pain isn’t just wear and tear—it’s a systemic, metabolic disease that starts years before symptoms show. In this episode, you’ll ...

Why You Still Feel Tired And Foggy On A Perfect Diet : 1348

19 Oct 2025

Contributed by Lukas

Biohacking isn’t just food + exercise, it’s about fixing the invisible disruptors wrecking your biology. EMFs, mold, toxins, mitochondrial stress,...

10 Minute Weekly Biohacking Update : 1347

17 Oct 2025

Contributed by Lukas

Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. TThis episode covers:• Longevity Scores Are Going MainstreamEle...

These Plants Turn On 1,100 Healing Genes In 24 Hours (Ancient Biohacks) : 1346

16 Oct 2025

Contributed by Lukas

Most people try to “heal” their brain with supplements, mindset, or meditation—but this episode reveals the deeper protocol to actually grow a n...

Solo Episode - Nicotine Masterclass (pt. 1) : 1345

14 Oct 2025

Contributed by Lukas

Nicotine isn’t just addictive—it might be one of the most misunderstood nootropics in modern medicine. In this masterclass, you’ll learn how con...

7 Toxic Foods POISONING Your Family's Health (Avoid These!) : 1344

13 Oct 2025

Contributed by Lukas

These "toxic foods" are one of the biggest hidden threats to your health and most people are eating them every single day without realizing it. These ...

The WATER Hack That Boosts Mitochondria by 11%! : 1343

10 Oct 2025

Contributed by Lukas

What if you could improve your mitochondria, oxygen efficiency, and recovery in just 20 minutes a day—by breathing energized water? This episod...

Digital Twins: The End of Human Drug Testing for Biohackers : 1342

09 Oct 2025

Contributed by Lukas

AI is transforming medicine at a speed never seen before. In this episode, you’ll discover how digital twins and artificial intelligence will revolu...

The Hidden Key to Pain-Free Joints (Longevity Tips) : 1341

07 Oct 2025

Contributed by Lukas

Most people think about heart disease and metabolism when they talk about longevity, but too few talk about joint health. In this episode, you’ll di...

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