
The mindbodygreen Podcast
601: How to improve GLP-1 levels, naturally | Colleen Cutcliffe, Ph.D.
Sun, 08 Jun 2025
“You can improve your metabolism simply through your microbiome,” explains Colleen Cutcliffe, Ph.D. Colleen Cutcliffe, Ph.D., biochemist, microbiologist, and the co-founder and CEO of Pendulum Therapeutics, joins us today to dive deep into the science of the gut microbiome, covering everything from the gut-metabolism axis and increasing GLP-1 levels to gut-supporting foods. Plus: - Starting her company, Pendulum (~2:45) - Assessing microbiome health (~6:25) - The gut-metabolism axis (~8:55) - Increasing GLP-1 naturally (~10:00) - What is Akkermansia (~13:00) - How to increase Akkermansia (~16:55) - Microbiome-supporting foods (~18:53) - How to change your microbiome (~24:45) - Environmental factors & the microbiome (~26:20) - Stress & the microbiome (~28:00) - Reset the gut after antibiotics (~28:45) - The future of microbiome science (~31:05) - Fecal transplants (~34:00) - Exciting new science (~35:55) Referenced in the episode: - Follow Colleen Cutcliffe on Instagram (@drcolleencutcliffe) - Check out her company (https://pendulumlife.com/) - Learn more about their research (https://pendulumlife.com/pages/research-clinical-trials#nav-clinical-trial) - Research on microbiome diversity & pet ownership (https://pmc.ncbi.nlm.nih.gov/articles/PMC7058978/) - Research on Akkermansia & response to cancer immunotherapy This episode is made in partnership with Pendulum’s Akkermansia. Made with a live strain of Akkermansia muciniphila, this supplement can improve gut health and digestion, reduce food cravings, and may even help stimulate GLP-1 production.*† Learn more at pendulumlife.com/MBG, and get 20% off all Pendulum product subscriptions for first orders. Discount applied at checkout. We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. †Based on pre-clinical studies. Not intended for weight loss. Learn more about your ad choices. Visit megaphone.fm/adchoices
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