The Co-Founders of Claude AI Tell Oprah About the Impact Artificial Intelligence Has on Your Life

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Previously titled “The Founders of Claude AI Tell Oprah About the Impact Artificial Intelligence Has on Your Life” — renamed by the publisher on Aug 4, 2026

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Recorded19 May 2026

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Show notes

The siblings and co-founders of Claude AI, the CEO, Dario Amodei, and the President, Daniela Amodei, sit down with Oprah for an in-depth discussion on Artificial Intelligence and its profound impact on all of us. Anthropic is one of the largest tech companies leading AI development including their enormously popular chatbot assistant Claude. Dario and Daniela discuss the ethical responsibility and moral questions that come with creating advanced A.I., their new model Mythos and share their thoughts around government regulation. They talk about the potential risks and benefits of A.I. in everyday lives, the impact on jobs and how it will affect children. The Amodei siblings also explain their headline-making refusal of the Pentagon’s request to remove guardrails from Claude and the behind-the-scenes discussions that helped shape their decision. 00:00:00 - Welcome Daniela and Dario Amodei, founders of Anthropic 00:01:47 - Dario on human extinction 00:04:40 - What is the AI race 00:08:00 - Athropic’s safety concerns 00:09:26 - Why they are a public benefit corporation 00:11:20 - How the siblings formed Anthropic 00:13:00 - Can AI be created responsibly 00:14:12 - Benefits and the harms 00:18:52 - People falling in love with AI 00:20:30 - Claude and underage users 00:22:18 - How Claude does not incentivize users 00:28:33 - Anthropic’s refusal to remove guardrails 00:35:10 - Hard decisions they have had to make 00;38:35 - What regulation should look like 00:40:45 - Should people view AI negatively? 00:43:00 - The AI problem to solve 00:48:20 - Men use AI more than women 00:49:30 - What is Mythos 00:53:20 - Does this keep them up at night? 00:54:15 - What keeps ego in check 00:58:20 - Will they get this right? 00:59:15 - Are there others doing this responsibly? 01:03:25 - What is the meaning of a well-lived life? Follow Oprah Winfrey on Social: https://www.instagram.com/oprahpodcast/ https://www.facebook.com/oprahwinfrey/ Listen to the full podcast: https://open.spotify.com/show/0tEVrfNp92a7lbjDe6GMLI https://podcasts.apple.com/us/podcast/the-oprah-podcast/id1782960381 Learn more about your ad choices. Visit megaphone.fm/adchoices

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