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The Oprah Podcast

Dr. Ania Jastreboff

14 Jan 2025

Transcription

Chapter 1: What are GLP-1 medications and how do they work?

870.462 - 870.722 Advertisement Narrator

Right.

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870.782 - 875.785 Oprah Winfrey

And they were wrong. And they were wrong. Now I know they were so wrong. Now I know why they were wrong.

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875.965 - 877.606

When you're living it, it is so hard.

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877.626 - 890.211 Oprah Winfrey

Yeah, of course, you blame yourself. It's so hard. And any person who's watching or listening to us right now who has suffered from obesity or being overweight, you know exactly what I'm talking about.

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890.491 - 915.27 Oprah Winfrey

You do not have to be on television every day to experience the same level of shame and embarrassment and why can't I do this and I'm so good at so many other things and I can take charge of my life and I can do all of this and why can't I? Right. outside world telling you that you are less than, that you should be shamed, feels like the punishment you deserve.

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And it's absolutely the opposite. It's absolutely the opposite. And none of this is in our control. Somehow in society, we think that how much we weigh is in our control. And it's not. It's not. Our brain is in control.

930.881 - 938.908 Oprah Winfrey

It's like the alcoholic finally realizing that it's not my willpower that caused me to not to be able to pick up the next drink.

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Yeah. And just like with alcohol, those reward motivation pathways, those regions in the brain really respond in a certain way when someone who has alcohol use disorder is drinking alcohol. In terms of obesity, those are the same brain pathways. Now, obesity is not an addiction. the thoughts of food and the wanting of food, that is something different.

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And again, that's- The food noise, we call that. It's a manifestation of the biology.

Chapter 2: Why is obesity considered a disease?

3276.257 - 3293.239 Oprah Winfrey

Thank you. Dr. Anya, it's always a joy to talk to you. Thank you so much for being here. We value your expertise on this topic. It must feel rewarding for you that this moment has finally come and that these medications are being made available to so many people because you get to see it in your own patients.

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Yeah, absolutely. I mean, I always say, people ask me, well, how did you know that you wanted to do this? The first time that I helped a patient lose a meaningful amount of weight for that person, I was like, I'm never doing anything ever again. This is it. And I'm so grateful that I get to do this. And I'm so grateful that patients trust me. They trust me to care for them.

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And, again, I couldn't imagine doing anything else.

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3322.526 - 3327.449 Oprah Winfrey

Well, I can see how rewarding it is because you have people saying, I got my life back.

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Yeah.

3328.03 - 3328.63 Oprah Winfrey

I got my life back.

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Absolutely. And, again, it's, you know, there's good and bad things about everything, everything in life. These medicines are right now what we're seeing. They're helping people transform their lives in so many ways in terms of their health, in terms of their overall life. They're just really incredible in terms of helping people.

3346.82 - 3370.469 Oprah Winfrey

Well, I want to thank you, Amy. Thank you, Amina. Thank you, Emma. Thank you for all of our guests sharing your stories. Go well, everybody. Thank you for making time to be with me today. I really hope that you join me for part two of this conversation as we continue to see how these new medications result in dramatic loss of weight, almost the equivalent of an entire person.

3370.549 - 3395.524 Oprah Winfrey

You've lost 165 pounds. Wow. Congratulations. So what happens in the aftermath of that? The doctor said to me, when are you going to stop blaming yourself and let somebody help you? When you lose up to 100 pounds or more, do people treat you differently? Everyone was so much friendlier to me. How does that impact how you see yourself in the world and even within your own family?

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