Today's episode dives into a not-so-well-known oral peptide supplement, formerly called AT-1001, and now referred to as larazotide acetate. We go over what this peptide does within the gut, how it blocks zonulin receptors, where to get it, why it's not well-known, and so much more! Truly, the research is pretty incredible and intriguing, so stay tuned... because this peptide could very well be the next game-changing supplement for "leaky gut!" Topics: 1. Discussion on Anti-Zonulin Peptide Compound - Introduction to the topic 2. The Gut Lining's Structure and Composition - Villi and Microvilli: Enhancing Surface Area - The presence and importance of crypts - Monolayer of epithelial cells explained 3. Different Types of Cells in the Gut Lining - Enterocytes: Absorption of Nutrients - Goblet Cells: Mucus Secretion - Paneth Cells: Antibacterial Function - M Cells: Immune Surveillance - Enteroendocrine Cells: Hormone Secretion - Stem Cells: Renewal and Replenishment 4. Tight Junctions: Ensuring Gut Integrity - Definition and importance of tight junctions - Components of tight junctions: Claudins, Occludin, JAMs - Interaction with the cytoskeleton through ZO proteins - Dynamic regulation in response to various conditions 5. Zonulin's Role in Intestinal Permeability - Gliadin's interaction with enterocytes leading to zonulin release - Zonulin's impact on the cytoskeleton and, therefore, tight junctions - Gliadin peptides' interaction with immune cells and celiac disease 6. Other Factors Influencing Zonulin Release and Gut Integrity - List of factors that directly or indirectly affect gut integrity 7. Larazotide Acetate: A Novel Peptide Compound - Definition and mechanism of action - Real-world implications and studies 8. Current State and Future of Larazotide Acetate - Studies and their discontinuation? - Its emergence in peptide supplement companies - The importance of consulting with medical professionals Thanks so much for tuning in! Order Chloe's Book "⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠" TODAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!

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“What did the council decide on item 42?” — answered with the speaker and the moment.

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