E44: L-Methylfolate (Deplin) and SAMe for the Treatment of Depression

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Recorded18 Jun 2025

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I introduced you to vitamins on the last episode and specifically concentrated on the B vitamins and more specifically, B12 and folate (B9). I touched on L-Methylfolate as the best way to supplement folate and that even if you are not deficient in folate that it may not be getting into your brain. If that's the case, then the patient may need L-Methylfolate. I will go into detail on it today. I will also cover SAMe which is related as it is a chemical in the methylation cycle that the folate cycle is connected to. Let's learn about these two supplements for depression that have pretty good evidence for benefit in patients!

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