#601: Folate vs. Folic Acid and the Importance of B12 and B6 as the Methylation Team

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Previously titled “#601: MTHFR Explained Part 1: Folate vs. Folic Acid and the Importance of B12 and B6 as the Methylation Team” — renamed by the publisher on Aug 4, 2026

Vitality Radio Podcast with Jared St. Clair not yet transcribed

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Recorded03 Jan 2026

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Handlerec:15083575

Show notes

On this episode of Vitality Radio, Jared is joined by his wife Jen to explore how folic acid, a synthetic B vitamin, is affecting our health - and the role of genetics in it all. What began as a simple dietary change unexpectedly revealed how folic acid in fortified foods, different forms of B vitamins, and individual genetics can significantly influence mood, energy, and mental clarity. Jared and Jen share their personal experience removing folic acid, adjusting B12 forms, and learning why some people thrive on methylated B vitamins while others feel worse. You’ll learn the key differences between folic acid and folate, why more supplementation isn’t always better, how B12 forms like methylcobalamin, hydroxocobalamin, and adenosylcobalamin behave differently in the body, and why B6, B12, and folate must work together as a team. This episode provides a practical framework for understanding why “doing everything right” doesn’t always lead to optimal results—and how thoughtful experimentation, label reading, and food quality make a meaningful difference.B Vitamin Products DiscussedAdditional Information:Episode #601 Blog Post#505: Emotional Vitality: Jen's Story Part 5 - The Impact of Diet on Mental Health and Physical PainCheck out all five“Jen’s Story” Episodes!Visit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

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