Serotonin syndrome is a potentially life-threatening toxicologic emergency caused by excess serotonergic activity. Early recognition is critical in the emergency department, ICU, inpatient wards, and prehospital settings. In this episode, we review the fundamentals of serotonin syndrome including: • Pathophysiology • Serotonergic medications • Hyperthermia • Clonus and hyperreflexia • Neuromuscular findings • Autonomic instability • Differential diagnosis • Serotonin syndrome vs neuroleptic malignant syndrome (NMS) • ICU and emergency department management • Supportive care strategies • Benzodiazepines and cyproheptadine This episode is designed for physicians, nurses, pharmacists, trainees, respiratory therapists, and anyone interested in emergency critical care medicine and toxicology. 🎥 YouTube video: https://www.youtube.com/watch?v=GoinGYGfs8k 📚 Download the study guide + access our complete emergency critical care curriculum: https://www.patreon.com/c/WhiteBoardMedicine Our Patreon includes: • PDF study guides for every episode • Emergency critical care mini-courses • Practice questions • Ad-free content • A structured ICU curriculum 🎧 WhiteBoard Medicine Podcast: https://podcasts.apple.com/us/podcast/whiteboard-medicine-emergency-and-critical-care/id1808306430 DISCLAIMER: This content is intended for educational purposes only and should not be considered medical advice. Clinical decisions should always be made using independent medical judgment, current guidelines, institutional protocols, and consultation with appropriate specialists. This content does not establish a physician-patient relationship and may not reflect the views of any affiliated institutions or employers.

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“What did the council decide on item 42?” — answered with the speaker and the moment.

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