Tumor lysis syndrome is an oncologic emergency caused by rapid tumor cell breakdown and release of intracellular contents into the bloodstream. In this episode, we review the pathophysiology, risk factors, laboratory abnormalities, diagnostic criteria, prevention, and treatment of tumor lysis syndrome. Topics covered include: • What tumor lysis syndrome is • Why tumor lysis syndrome occurs • High-risk cancers and clinical risk factors • Hyperkalemia • Hyperphosphatemia • Hypocalcemia • Hyperuricemia • Acute kidney injury • Cairo-Bishop diagnostic criteria • Laboratory monitoring and risk stratification • IV fluids and prevention strategies • Allopurinol and rasburicase • Management of electrolyte abnormalities • Renal replacement therapy considerations • Practical emergency and critical care considerations Watch the full video on YouTube: https://www.youtube.com/watch?v=mPippZYtK54 📚 Join the WhiteBoard Medicine Patreon Community https://www.patreon.com/WhiteBoardMedicine Join a growing emergency medicine, critical care, and resuscitation education community built around high-yield clinical learning. Patreon members get access to: • Comprehensive Study Guides • Bedside One-Pagers • Clinical Reviews • Mini-Courses • Practice Questions • Ad-Free Videos • Structured Topic Collections 🌐 WhiteBoard Medicine Website Explore our growing library of critical care and emergency medicine content: https://www.whiteboardmedicine.com ⚠️ Educational Disclaimer: This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care. Full disclaimer: https://whiteboardmedicine.com/disclaimer

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“What did the council decide on item 42?” — answered with the speaker and the moment.

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