Norepinephrine is one of the most important vasopressors in emergency medicine and critical care. In this masterclass episode, we review the foundations of norepinephrine, including mechanism of action, receptor effects, hemodynamics, dosing, adverse effects, and monitoring, then take a deeper dive into clinical scenarios and bedside applications where norepinephrine is commonly used. Topics covered include: • What norepinephrine is • Norepinephrine mechanism of action • Alpha-1, beta-1, and beta-2 receptor effects • Hemodynamic effects on vascular tone and cardiac output • Norepinephrine dosing and titration • Central versus peripheral administration • Norepinephrine adverse effects and monitoring • Norepinephrine in septic shock • Norepinephrine in distributive shock • Norepinephrine in cardiogenic shock • Norepinephrine in hemorrhagic shock • Norepinephrine in post-intubation hypotension • Norepinephrine and bradycardia • Norepinephrine versus epinephrine • Norepinephrine versus phenylephrine • Extravasation and safety considerations • Practical bedside norepinephrine scenarios Watch the full video on YouTube: https://www.youtube.com/watch?v=vFjL5sp3MSk 📚 Want More Emergency & Critical Care Medicine Education? Join the WhiteBoard Medicine Patreon community: https://www.patreon.com/WhiteBoardMedicine Patreon members receive access to: • Downloadable Study Guides • Clinical One-Pagers • Practice Questions • Mini-Courses • Comprehensive Clinical Reviews • Ad-Free Videos • Early Access Content 🌐 WhiteBoard Medicine Website Explore our growing library of critical care and emergency medicine content: https://www.whiteboardmedicine.com ⚠️ Educational Disclaimer: This content is intended for educational purposes only and should not be used as a substitute for clinical judgment, institutional protocols, specialist consultation, or individualized patient care. Full disclaimer: https://whiteboardmedicine.com/disclaimer

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