Anaphylaxis is a life-threatening systemic hypersensitivity reaction that can rapidly progress to anaphylactic shock, airway compromise, and cardiovascular collapse. Early recognition and treatment are essential to prevent mortality. In this episode, we provide a comprehensive review of anaphylaxis, beginning with epidemiology and underlying immunologic mechanisms including IgE-mediated mast cell and basophil activation. We review the pathophysiology of mediator release, vascular permeability, vasodilation, and bronchospasm that drive the clinical syndrome. We then cover classic and atypical symptoms, diagnostic considerations, and bedside evaluation strategies in emergency and critical care settings. Management is presented step-by-step, emphasizing early intramuscular epinephrine, airway protection, fluid resuscitation, adjunctive therapies, and monitoring. The second half of the episode focuses on a deep dive into anaphylactic shock, including hemodynamic profiles, refractory shock physiology, vasopressor selection, and escalation strategies for patients with persistent hypotension despite epinephrine. 📚 MINI COURSES, STUDY GUIDES (for this video), PRACTICE QUESTIONS, AD FREE VIDEOS, EDUCATIONAL DISCUSSIONS in our WBM Emergency Critical Care Patreon Community - Join Today!! https://www.patreon.com/c/WhiteBoardMedicine Playlist on Shock: https://youtube.com/playlist?list=PLf5bMa9_tvRjunk4I-rQZYPZn3qHqWFqW&si=kserFPPm7RYuhul- DISCLAIMER THIS PODCAST DOES NOT PROVIDE MEDICAL ADVICE. The information, including but not limited to, audio, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read, watched, or listened to on this video, or any other videos, reports, texts tweets or other sources.

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