What REALLY happens when you take a GLP-1 drug?Your fat loss, your muscle, your heart, your inflammation, what happens to your weight when you stop, and long-term safety.This episode covers body composition data from the 2026 semaglutide and tirzepatide trials, cardiovascular outcomes from SELECT and SURPASS-CVOT, inflammation findings beyond weight loss, weight regain patterns after stopping, and a 5-part framework to keep muscle on or off the drug after 40. Plus the 2026 safety update and recent Alzheimer's and Parkinson's research for adults considering, taking, or tapering off a GLP-1.Join Eat More Lift Heavy, the 26-week coached program where adults over 40 build the nutrition and training skills to preserve muscle, lose fat, and manage their physique for life.Timestamps:0:00 - The GLP-1 drug narratives 5:55 - Lean mass loss in STEP 1 and SURMOUNT-1 8:30 - Organ mass, muscle quality, and DXA 10:15 - STEP UP trial and higher-dose semaglutide 11:23 - Cardiovascular outcomes from SELECT and SURPASS-CVOT 13:00 - Inflammation markers and CRP reduction 14:00 - GLP-1s and neurodegeneration research 15:32 - Habits that outlast the drug 17:00 - What happens to your weight when you stop 19:30 - Exercise while taking GLP-1s and natural production 20:48 - 5-part framework for muscle preservation 26:55 - Safety signals and long-term effects 28:12 - 3 high-protein meals when you don't have an appetite💪 Join Eat More Lift Heavy - A 6-month coaching program for lifters over 40 who are done collecting information and ready to have real human coaches watch their data and know what to focus on each week.📱 Get Fitness Lab (exclusive 20% off) - The #1 adaptive fitness and nutrition app. Daily coaching, workouts, and biofeedback-based guidance to help you build muscle and lose fat over 40.👥 Join our Facebook community - For adults over 40 who want to build muscle, lose fat, and stop following bad advice. Weekly Q&A threads, coaching insights, and real chat with other lifters.👋 Ask a question or find Philip Pape on Instagram

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“What did the council decide on item 42?” — answered with the speaker and the moment.

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